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Titolo:
Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency
Autore:
Arai, T; Tsukada, T; Murase, T; Matsumoto, K;
Indirizzi:
Toranomon Gen Hosp, Dept Clin Chem, Minato Ku, Tokyo 1058470, Japan Toranomon Gen Hosp Tokyo Japan 1058470 , Minato Ku, Tokyo 1058470, Japan Toranomon Gen Hosp, Dept Endocrinol & Metab, Minato Ku, Tokyo 1058470, Japan Toranomon Gen Hosp Tokyo Japan 1058470 , Minato Ku, Tokyo 1058470, Japan Toho Univ, Sch Pharmaceut Sci, Dept Clin Chem, Chiba 2748510, Japan Toho Univ Chiba Japan 2748510 Sci, Dept Clin Chem, Chiba 2748510, Japan
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 301, anno: 2000,
pagine: 103 - 117
SICI:
0009-8981(200011)301:1-2<103:PSAOHD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRADIENT GEL-ELECTROPHORESIS; CORONARY HEART-DISEASE; CLINICAL IMPLICATIONS; TRANSGENIC MICE; SPLICING DEFECT; RAPID DETECTION; MUTATION; PLASMA; HYPERALPHALIPOPROTEINEMIA; TRANSPORT;
Keywords:
cholesteryl ester transfer protein (CETP); high-density lipoproteins (HDL); particle size;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, T Toranomon Gen Hosp, Dept Clin Chem, Minato Ku, 2-2-2 Toranomon, Tokyo 1058470, Japan Toranomon Gen Hosp 2-2-2 Toranomon Tokyo Japan 1058470 470, Japan
Citazione:
T. Arai et al., "Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency", CLIN CHIM A, 301(1-2), 2000, pp. 103-117

Abstract

We investigated the detailed distribution of high-density lipoproteins (HDL) particle size in patients with cholesteryl ester transfer protein (CETP)deficiency. Serum samples pre-stained with Sudan black B were electrophoresed using 4-30% polyacrylamide gradient gels, and the Stokes diameter of HDL particles was determined in 23 patients with genetic CETP deficiency, nine patients with hyperalphalipoproteinemia and seven subjects with normal HDL cholesterol concentrations. The mean Stokes diameter of HDL particles in CETP deficient patients (11.2 +/- 0.6 nm) was significantly greater than hyperalphalipoproteinemia (107 +/- 0.3 nm, P < 0.05) and normal subjects (9.5<plus/minus> 0.4 nm, P < 0.01). A significant relationship was found between mean HDL size and serum CETP mass concentrations (P < 0.05). When the particle size of all detected HDL bands was investigated, extra-large HDL particles larger than 12 nm were found in 14 of the 23 patients with CETP deficiency, which were not found in any of the hyperalphalipoproteinemia patients or normal subjects. Serum low-density lipoproteins (LDL) cholesterol andtotal cholesterol concentrations were lower in CETP deficiencies with extra-large HDL particles than those in non-carriers (P < 0.01). These results indicate that extra-large HDL may be an index to clarify the relationship between genetic CETP deficiency and atherosclerosis. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:48:26