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Titolo:
Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile(105)Val polymorphism
Autore:
Sweeney, C; McClure, GY; Fares, MY; Stone, A; Coles, BF; Thompson, PA; Korourian, S; Hutchins, LF; Kadlubar, FF; Ambrosone, CB;
Indirizzi:
Univ Arkansas Med Sci, Arkansas Canc Res Ctr, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA Natl Ctr Toxicol Res, Jefferson, AR 72079 USA Natl Ctr Toxicol Res Jefferson AR USA 72079 Res, Jefferson, AR 72079 USA Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 tr, Dept Epidemiol, Houston, TX 77030 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 20, volume: 60, anno: 2000,
pagine: 5621 - 5624
SICI:
0008-5472(20001015)60:20<5621:ABSATF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC POLYMORPHISMS; EXPRESSION; PI; CHEMOTHERAPY; CYTOCHROME-P450; SUSCEPTIBILITY; CONJUGATION; ISOENZYMES; RESISTANCE; VARIANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sweeney, C Univ Arkansas Med Sci, Arkansas Canc Res Ctr, 4301 W Markham St,Slot 795, Little Rock, AR 72205 USA Univ Arkansas Med Sci 4301 W Markham St,Slot 795 Little Rock AR USA 72205
Citazione:
C. Sweeney et al., "Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile(105)Val polymorphism", CANCER RES, 60(20), 2000, pp. 5621-5624

Abstract

A glutathione S-transferase (GST) P1 polymorphism results in an amino acidsubstitution, Ile(105)Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy, We evaluated survival according to GSTP1 genotype among women (a = 240) treated Pur breast cancer. Women with the low-activity Val/Val genotype had better survival. Compared with Ile/Ile, hazard ratios for overall survival were 0.8 (95% confidence interval, 0.5-1.3) for Ile/Val and 0.3 (95% confidence interval, 0.1-1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability may influence treatment outcomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:21:23