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Titolo:
Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer
Autore:
Miyamoto, S; Baba, H; Kuroda, S; Kaibuchi, K; Fukuda, T; Maehara, Y; Saito, T;
Indirizzi:
Kyushu Natl Canc Ctr, Gynecol Serv, Minami Ku, Fukuoka 8111395, Japan Kyushu Natl Canc Ctr Fukuoka Japan 8111395 mi Ku, Fukuoka 8111395, Japan Nara Inst Sci & Technol, Div Signal Transduct, Nara 6300101, Japan Nara Inst Sci & Technol Nara Japan 6300101 ransduct, Nara 6300101, Japan Kyushu Univ, Fac Med, Dept Surg 2, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 2, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 9, volume: 83, anno: 2000,
pagine: 1168 - 1175
SICI:
0007-0920(200011)83:9<1168:CIEAWC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; ALPHA-CATENIN EXPRESSION; HUMAN GASTRIC-CANCER; RAC1 SMALL GTPASES; BETA-CATENIN; TYROSINE PHOSPHORYLATION; IMMUNOHISTOCHEMICAL EVALUATION; MDCK CELLS; PROTEIN; COMPLEX;
Keywords:
IQGAP1; alpha-catenin; E-cadherin; endometrial cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Miyamoto, S Kyushu Natl Canc Ctr, Gynecol Serv, Minami Ku, Notame 3-1-1, Fukuoka 8111395, Japan Kyushu Natl Canc Ctr Notame 3-1-1 Fukuoka Japan 8111395 Japan
Citazione:
S. Miyamoto et al., "Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer", BR J CANC, 83(9), 2000, pp. 1168-1175

Abstract

E-cadherin function is thought to be impaired in epithelial cancer. To investigate the alterations in E-cadherin associated with cytoplasmic molecules including alpha -catenin, beta -catenin, gamma -catenin, p120CAS, and IQGAP1 in various endometrial cancers with different degree of differentiation, we examined the localization and expression of E-cadherin and cytoplasmicmolecules in 30 cases of both well and poorly differentiated endometrioid adenocarcinomas, using immunofluorescence and immunoblotting techniques. E-cadherin and cytoplasmic molecules demonstrated linear staining at the cellboundaries in normal endometrium. In all 20 cases with well differentiatedadenocarcinomas, alpha -catenin and IQGAP1 disappeared from the cell adhesive sites, but other cytoplasmic molecules were co-localized with E-cadherin along the cell boundaries. In all 20 cases with poorly differentiated adenocarcinomas, E-cadherin and cytoplasmic molecules accumulated as large aggregates along cell adhesive sites, and the localization of IQGAP1 differed from those of other cytoplasmic molecules, The expression of these molecules in all 20 cases with well differentiated adenocarcinomas decreased or waslost in Triton-insoluble fraction, in comparison with the findings for allcases with normal endometrium or poorly differentiated adenocarcinomas, These results suggested that each alteration in E-cadherin associated with cytoplasmic molecules may play a different role in E-cadherin dysfunction between well and poorly differentiated adenocarcinomas. (C) 2000 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 19:35:47