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Titolo:
Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures
Autore:
Cohen, RM; Carson, RE; Saunders, RC; Doudet, DJ;
Indirizzi:
NIMH, Geriatr Psychiat Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 r Psychiat Branch, NIH, Bethesda, MD 20892 USA NIMH, Cerebral Metab Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 MH, Cerebral Metab Lab, Bethesda, MD 20892 USA NIH, PET Dept, Ctr Clin, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892NIH, PET Dept, Ctr Clin, Bethesda, MD 20892 USA NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 879, anno: 2000,
pagine: 1 - 6
SICI:
0006-8993(20001006)879:1-2<1:ORAIII>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPER-SENSITIVITY; RAT-BRAIN; KAPPA; ENKEPHALIN; AGONISTS; DECREASE; DISEASE; BINDING; DORSAL; MPTP;
Keywords:
neurodegeneration; 6-deoxy-6-beta-[F-18]fluoronaltrexone; positron emission tomography; cortex; visual system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, RM NIMH, Geriatr Psychiat Branch, NIH, Bldg 10,Room 3N218,10 Ctr Dr,MSC 1274,Bethesda, MD 20892 USA NIMH Bldg 10,Room 3N218,10 Ctr Dr,MSC 1274Bethesda MD USA 20892
Citazione:
R.M. Cohen et al., "Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures", BRAIN RES, 879(1-2), 2000, pp. 1-6

Abstract

Opiate receptor avidity (B-max'/K-D) was measured in four rhesus monkeys following unilateral lesioning of the optic tract combined with transection of the corpus callosum and the hippocampal and anterior commissures depriving one hemisphere of visual input (Tract and Split), two animals with transection of commissures only (Split), and nine healthy monkeys with positron emission tomography (PET) and 6-deoxy-6-beta-[F-18]fluoronaltrexone (cyclofoxy, CF), a mu- and kappa -opiate receptor antagonist. Opiate receptor avidity was found to be significantly higher in the Tract and Split animals, only, bilaterally, throughout the lateral cortex and in the cingulate and posterior putamen (41-117%). Ipsilateral changes were consistently greater than those contralateral, but this asymmetry was of statistical significance only in the parietal and occipital cortices. Cyclofoxy avidity was decreasedin the medial cortex of both the Tract and Split and Split animals (similar to 25%), The results suggest that opiate pathways undergo extensive alteration in response to changes in brain functional activities brought about through hemispheric visual deprivation. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/09/20 alle ore 05:38:00