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Titolo:
NEGATIVE LOW EXPRESSION OF THE MET/HEPATOCYTE GROWTH-FACTOR RECEPTOR IDENTIFIES PAPILLARY THYROID CARCINOMAS WITH HIGH-RISK OF DISTANT METASTASES/
Autore:
BELFIORE A; GANGEMI P; COSTANTINO A; RUSSO G; SANTONOCITO GM; IPPOLITO O; DIRENZO MF; COMOGLIO P; FIUMARA A; VIGNERI R;
Indirizzi:
OSPED GARIBALDI,CATTEDRA ENDOCRINOL,IST MED INTERNA & MALATTIE ENDOCRINE METAB I-95123 CATANIA ITALY UNIV CATANIA,CATTEDRA ENDOCRINOL,IST MED INTERNA & MALATTIE ENDOCRINE& METAB I-95124 CATANIA ITALY OSPED V EMANUELE II,SERV ANAT PATHOL CATANIA ITALY UNIV CATANIA,CATTEDRA CHIRURG I-95124 CATANIA ITALY UNIV TURIN,DIPARTIMENTO SCI BIOMED & ONCOL TURIN ITALY
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 7, volume: 82, anno: 1997,
pagine: 2322 - 2328
SICI:
0021-972X(1997)82:7<2322:NLEOTM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MET HGF RECEPTOR; FACTOR SCATTER FACTOR; C-MET; EPITHELIAL-CELLS; BREAST-CANCER; TYROSINE KINASE; ONCOGENE; OVEREXPRESSION; NODULES; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Belfiore et al., "NEGATIVE LOW EXPRESSION OF THE MET/HEPATOCYTE GROWTH-FACTOR RECEPTOR IDENTIFIES PAPILLARY THYROID CARCINOMAS WITH HIGH-RISK OF DISTANT METASTASES/", The Journal of clinical endocrinology and metabolism, 82(7), 1997, pp. 2322-2328

Abstract

To investigate the clinical impact of Met/hepatocyte growth factor receptor (HGF-R) expression in thyroid cancer we studied 163 thyroid carcinomas (129 papillary, 21 follicular, and 13 anaplastic) from patients followed-up for 25-147 months postthyroidectomy. Forty-nine thyroid adenomas were also studied. Met/HGF-R expression was evaluated by semiquantitative immunohistochemistry, measuring both the proportion (scale of 0-5) and the intensity (scale, 0-5) of stained cells and calculating a total score (scale of 0-10). Met/HGF-R was absent in the normal thyroid tissue, absent or focally expressed in follicular and anaplastic tumors, and expressed at various levels in most papillary carcinomas, including microcarcinomas. Papillary carcinomas were thus categorized as having negative/low Met/HGF-R (n = 50; total score, less than orequal to 5) or high Met/HGF-R expression (n = 70; total score, >5). High Met/HGF-R was inversely associated with vascular invasion (P = 0.0308), but not with other prognostic factors. Negative/low Met/HGF-R expression was the most effective predictor by multivariate Cox analysisof distant metastases (hazard ratio = 9.71; P = 0.0036), higher than extrathyroid invasion (hazard ratio = 4.25; P = 0.0181), age (less than or equal to 45 vs. >45 yr; hazard ratio = 3.99; P = 0.0099), and vascular invasion (hazard ratio = 3.19; P = 0.0358). These findings suggest a role for Met/HGF-R in papillary thyroid cancer and its clinical use to select patients with a high risk of distant metastases.

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Documento generato il 26/11/20 alle ore 07:44:54