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Titolo:
Ventricular fibrillation threshold and local dispersion of refractoriness in isolated rabbit hearts with left ventricular dysfunction
Autore:
Burton, FL; McPhaden, AR; Cobbe, SM;
Indirizzi:
Univ Glasgow, Dept Med Cardiol, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland Univ Glasgow, Dept Med Pathol, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland
Titolo Testata:
BASIC RESEARCH IN CARDIOLOGY
fascicolo: 5, volume: 95, anno: 2000,
pagine: 359 - 367
SICI:
0300-8428(200010)95:5<359:VFTALD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE HEARTS; MECHANOELECTRICAL FEEDBACK; MYOCARDIAL-INFARCTION; CARDIAC-FAILURE; VOLUME LOAD; ARRHYTHMIA; DEATH; ARRHYTHMOGENESIS; TACHYCARDIA; INTERVALS;
Keywords:
heart failure; electrophysiology; epicardial mapping; ventricular dilatation; arrhythmia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Burton, FL Univ Glasgow, Dept Med Cardiol, W Med Bldg, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow W Med Bldg Glasgow Lanark Scotland G12 8QQ cotland
Citazione:
F.L. Burton et al., "Ventricular fibrillation threshold and local dispersion of refractoriness in isolated rabbit hearts with left ventricular dysfunction", BAS R CARD, 95(5), 2000, pp. 359-367

Abstract

Patients with congestive heart failure or left ventricular dysfunction (LVD) have a high incidence of ventricular tachyarrhythmias and sudden cardiacdeath. In addition to structural, metabolic and neuroendocrine changes, mechanoelectrical feedback may play a role in arrhythmogenesis in heart failure. Three groups of rabbits (n = 10 for each) were studied: chronic coronary ligation with ejection fraction (EF) greater than or equal to 0.45 or < 0.45, and sham-operated controls. Ventricular fibrillation (VF) thresholds were measured at LV pressures of 0 and 40 mmHg during modified Langendorff perfusion. Intervals between local activations during VF (VFI) were used as an index of refractoriness. Global dispersion was expressed as coefficient of variation of VFI; local dispersion by maximum difference in VFI between adjacent sites. Median VF threshold was lower at 0mmHg in the lower EF group compared to controls (30 vs 67.5 mA, P < 0.05). VF threshold in control hearts was lower at 40 mmHg than at 0 mmHg (P < 0.01), but there was no further reduction in threshold in LVD hearts at 40mmHg. Global dispersion of VFI did not differ significantly between groups. Local dispersion of VFI in the lower EF group was greater than in controls at 0mmHg in the infarct border zone (P < 0.05). At 40 mmHg, local dispersion of VFI in zones bordering and remote from the infarct were greater in both LVD groups than in controls (P < 0.05). Local inhomogeneity of refractoriness is more marked in the infarct border zone, but latent abnormalities are evident in normal myocardium of rabbits with left ventricular dysfunction and are revealed by left ventricular distension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 10:38:53