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Titolo:
SEX-RELATED DIFFERENCE IN THE GROWTH OF PROLACTINOMAS - A CLINICAL AND PROLIFERATION MARKER STUDY
Autore:
DELGRANGE E; TROUILLAS J; MAITER D; DONCKIER J; TOURNIAIRE J;
Indirizzi:
UNIV HOSP UCL MONT GODINNE,DEPT INTERNAL MED & ENDOCRINOL B-5530 YVOIR BELGIUM RTH LAENNEC,FAC MED LYON,INSERM,U369 F-69372 LYON 08 FRANCE RTH LAENNEC,FAC MED LYON,LAB HISTOL EMBRYOL F-69372 LYON 08 FRANCE UCL ST LUC,DEPT ENDOCRINOL & NUTR B-1200 BRUSSELS BELGIUM UNIV LYON 1,CLIN ENDOCRINOL,HOP ANTIQUAILLE F-69321 LYON 05 FRANCE
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 7, volume: 82, anno: 1997,
pagine: 2102 - 2107
SICI:
0021-972X(1997)82:7<2102:SDITGO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADENOMAS; DOPAMINE AGONISTS; MEN; TUMORS; HYPERPROLACTINEMIA; BROMOCRIPTINE; MACROADENOMAS; RESISTANCE; THERAPY; KI-67;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
E. Delgrange et al., "SEX-RELATED DIFFERENCE IN THE GROWTH OF PROLACTINOMAS - A CLINICAL AND PROLIFERATION MARKER STUDY", The Journal of clinical endocrinology and metabolism, 82(7), 1997, pp. 2102-2107

Abstract

Prolactinomas in women commonly present as small intrasellar tumors, but are usually much larger in men. This discrepancy has generally been attributed to differences in the delay before diagnosis. However, studies comparing clinical and pathological correlates of growth of these tumors in both sexes are lacking. We conducted a retrospective studycomparing 45 men and 51 women bearing prolactinoma to determine whether the predominance of large tumors in men was due to a delay in diagnosis or, rather, to a fundamental sex-related difference in tumor growth. Basal PRL levels (mean +/- SEM, 2789 +/- 573 ng/mL) and mean tumordiameter (26 +/- 2 mm) were significantly higher in men than in women(292 +/- 74 ng/mL and 10 +/- 1 mm, respectively; P < 0.001), but werenot correlated to the age at diagnosis or the duration of symptoms. Giant tumors (n = 8) occurred in males only. The frequencies of bromocriptine-resistant tumors (30 vs. 5%; P < 0.01) and invasive macroadenomas (52 vs. 27%; P < 0.001) were significantly greater in men than those in women. Lastly, macroprolactinomas in males exhibited higher indexes of proliferating cells by Ki-67 immunoreactivity (2.6 +/- 1.1% of positive nuclei) than did similar tumors in female patients (0.4 +/- 0.2%; P = 0.08). We conclude that the predominance of large prolactinomas in men is due to a high frequency of rapidly growing tumors, which are often invasive and frequently bromocriptine resistant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:29:01