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Titolo:
Differences in reproductive endocrinology between Asian men and Caucasian men - a literature review
Autore:
van Houten, ME; Gooren, LJG;
Indirizzi:
Vrije Univ Amsterdam Hosp, Dept Endocrinol, Androl Unit, Amsterdam, Netherlands Vrije Univ Amsterdam Hosp Amsterdam Netherlands Amsterdam, Netherlands
Titolo Testata:
ASIAN JOURNAL OF ANDROLOGY
fascicolo: 1, volume: 2, anno: 2000,
pagine: 13 - 20
SICI:
1008-682X(200003)2:1<13:DIREBA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-BINDING GLOBULIN; ANDROGEN RECEPTOR GENE; ENANTHATE-INDUCED AZOOSPERMIA; PROSTATE-SPECIFIC ANTIGEN; NORMAL CHINESE MEN; LUTEINIZING-HORMONE; UNITED-STATES; 5-ALPHA-REDUCTASE ACTIVITY; PHYSICAL-ACTIVITY; RISK-FACTORS;
Keywords:
ethnology; Asian men; Caucasian men; prostatic neoplasms; endocrinology; male contraceptive agents; androgen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Gooren, LJG Endo AZVU, POB 7057, NL-1007 MB Amsterdam, Netherlands Endo AZVU POB 7057 Amsterdam Netherlands NL-1007 MB therlands
Citazione:
M.E. van Houten e L.J.G. Gooren, "Differences in reproductive endocrinology between Asian men and Caucasian men - a literature review", ASIAN J AND, 2(1), 2000, pp. 13-20

Abstract

This review provides an overview of the literature on aspects of reproductive endocrinology wherein Asian men may differ from Caucasian, notably, prostatic nioplasm and the sensivity to pharmacological regimens of male contraception. Both genetic and environmental factors, such as nutrition, might be relevant. Asian men residing in Asia seem to be relatively protected from clinical prostatic nioplasm while the prevalence of preclinical prostaticnioplasm is not different. Migration to an area with a higher prevalence reduces this difference but does not undo it. With regard to prostatic nioplasm the following factors have been considered as relevant in Asian men: 1)a reduction in 5 alpha -reductase level, 2) decreased levels of androgenicketosteroid precursors of 5 alpha -reduced androgen metabolites, 3) the decreased presence of a P53 mutation, 4) a higher GAG-repeat length of the androgen receptor, 5) a possible higher level of physical activity, 6) differences in sexual activity. Furthermore, Asian men respond to a higher degreewith azoospermia in response to contraceptive steroids. Possible explanations offered for the more pronounced response to contraceptive steroids are:1) differences in testicular structure and decreased spermatogenic potential, 2) an earlier and more marked suppression in LH secretion by exogenous androgens. The differences may be due to genetical and/or environmental factors influencing the peripheral testosterone metabolism. Dietary factors such as the higher intake of phytoestrogens in Asians might exert effects on Sa-reductase activity and/or on sex hormone binding globulin (SHBG) levels,thus having an impact on the biological efficay of circulating androgens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:00:37