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Titolo:
Antifibrotic effect of Stephania tetrandra on experimental liver fibrosis induced by bile duct ligation and scission in rats
Autore:
Nan, JX; Park, EJ; Lee, SH; Park, PH; Kim, JY; Ko, GN; Sohn, DH;
Indirizzi:
Wonkwang Univ, Coll Pharm, Med Resources Res Ctr, Iksan 570749, Cheonbuk, South Korea Wonkwang Univ Iksan Cheonbuk South Korea 570749 49, Cheonbuk, South Korea
Titolo Testata:
ARCHIVES OF PHARMACAL RESEARCH
fascicolo: 5, volume: 23, anno: 2000,
pagine: 501 - 506
SICI:
0253-6269(200010)23:5<501:AEOSTO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIARY OBSTRUCTION; GANODERMA-LUCIDUM; HEPATIC-FIBROSIS; PENTOXIFYLLINE; INHIBITION; HEPATOCYTE; ACTIVATION; CIRRHOSIS; COLLAGEN; CULTURE;
Keywords:
bile duct ligation and scission; Stephania tetrandra; liver fibrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sohn, DH Wonkwang Univ, Coll Pharm, Med Resources Res Ctr, Iksan 570749, Cheonbuk, South Korea Wonkwang Univ Iksan Cheonbuk South Korea 570749 buk, South Korea
Citazione:
J.X. Nan et al., "Antifibrotic effect of Stephania tetrandra on experimental liver fibrosis induced by bile duct ligation and scission in rats", ARCH PH RES, 23(5), 2000, pp. 501-506

Abstract

We examined the antifibrotic effect of a methanol extract from Stephania tetrandra (ST) on experimental liver fibrosis. Liver fibrosis was induced bybile duct ligation and scission (BDL/S) in rats. In BDL/S rats, activity levels of aspartate transaminase (AST), alanine transaminse (ALT), alkaline phosphatase (ALP), concentration of total bilirubin in serum, and hydroxyproline content of the liver were significantly increased. The ST treatment (either 100 mg/kg/day or 200 mg/kg/day, p.o. for 4 weeks) in BDL/S rats reduced the serum AST, ALT and ALP activity levels significantly (p<0.01). Similarly, when compared to the control group, the concentration of hydroxyproline in the livers of the BDL/S rats treated with 100mg or 200mg ST treated rats decreased by 40% and 33% respectively, when compared to the BDL/S control group (p<0.01). The morphological characteristics of fibrotic liver that were observed in the BDL/S control group, improved in the ST treated BDL/S group. In the fibrotic liver of BDL/S rats treated with ST, a marked reduction in the numbers of alpha smooth muscle cell actin positive stellate cells was observed. These results indicate that doses of either 100 or 200 mg/kg/day of methanol extract from S. tetrandra, had an antifibrotic effect in rats with liver fibrosis induced by bile duct ligation and scission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:37:45