Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: Identification of gyrA and parC and specification of point mutations associated with resistance
Autore:
Yan, SS; Fox, ML; Holland, SM; Stock, F; Gill, VJ; Fedorko, DP;
Indirizzi:
NIAID, Microbiol Serv, CPD, Ctr Clin,NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 rv, CPD, Ctr Clin,NIH, Bethesda, MD 20892 USA NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 ID, Host Def Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 11, volume: 44, anno: 2000,
pagine: 3196 - 3198
SICI:
0066-4804(200011)44:11<3196:RTMFIA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO ACTIVITIES; DNA GYRASE; TOPOISOMERASE-IV; PNEUMONIAE; SPARFLOXACIN; QUINOLONES; INFECTIONS; SUBUNIT; TARGETS; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Fedorko, DP NIAID, Microbiol Serv, CPD, Ctr Clin,NIH, 9000 Rockville Pike,Bldg 10,Rm 2C385, Bethesda, MD 20892 USA NIAID 9000 Rockville Pike,Bldg 10,Rm 2C385 Bethesda MD USA 20892
Citazione:
S.S. Yan et al., "Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: Identification of gyrA and parC and specification of point mutations associated with resistance", ANTIM AG CH, 44(11), 2000, pp. 3196-3198

Abstract

A strain of Streptococcus pyogenes resistant to multiple fluoroquinolones was isolated from the blood of an immunocompromised patient. Resistance to fluoroquinolones in S. pyogenes has not been previously studied. Compared to 10 sensitive strains of S. pyogenes, the fluoroquinolone-resistant clinical isolate of S, pyogenes presented point mutations in gyrA, predicting that serine-81 was changed to phenylalanine and that methionine-99 was changedto leucine, and in parC, predicting that serine-79 was changed to tyrosine. The mechanism of fluoroquinolone resistance in this isolate of S. pyogenes appears to be analogous to previously reported mechanisms for Streptococcus pneumoniae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:21:58