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Titolo:
Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex
Autore:
Kuhl, DE; Minoshima, S; Frey, KA; Foster, NL; Kilbourn, MR; Koeppe, RA;
Indirizzi:
Univ Michigan, Div Nucl Med, Dept Internal Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 nternal Med, Ann Arbor, MI 48109 USA Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Neurol, Ann Arbor, MI 48109 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 3, volume: 48, anno: 2000,
pagine: 391 - 395
SICI:
0364-5134(200009)48:3<391:LDIOAM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; CHOLINERGIC HYPOTHESIS; DISEASE; DEMENTIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kuhl, DE Univ Michigan Hosp, Div Nucl Med, Room B1 G505-0028, Ann Arbor, MI 48109 USA Univ Michigan Hosp Room B1 G505-0028 Ann Arbor MI USA 48109 9 USA
Citazione:
D.E. Kuhl et al., "Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex", ANN NEUROL, 48(3), 2000, pp. 391-395

Abstract

Based on surrogate assays of peripheral red blood cells, reports state that widely prescribed doses of donepezil hydrochloride provide nearly complete inhibition of cerebral cortical acetylcholinesterase activity in the treatment of Alzheimer's disease (AD). To test this, direct positron emission tomography measures of cerebral acetylcholinesterase activity were made in AD patients before and after treatment with donepezil (5 and 10 mg/ day) forat least 5 weeks and compared with similar measures in normal controls whowere untreated or after acute administration of another AChE inhibitor, physostigmine salicylate (1.5 mg/hr). After physostigmine, acetylcholinesterase inhibition averaged 52% in normal cerebral cortex. After donepezil, cerebral cortical inhibition in AD brain averaged only 27%. Clinical trials of this donepezil dose schedule are not testing the effect of nearly complete cerebral cortical inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:47:09