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Titolo:
Baroreceptor sensitivity of rat supraoptic vasopressin neurons involves noncholinergic neurons in the DBB
Autore:
Grindstaff, RJ; Grindstaff, RR; Cunningham, JT;
Indirizzi:
Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri, Dept Physiol, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Physiol, Columbia, MO 65211 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: R1934 - R1943
SICI:
0363-6119(200011)279:5<R1934:BSORSV>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC MAGNOCELLULAR NEURONS; METABOTROPIC GLUTAMATE RECEPTORS; DIAGONAL BAND; MEDIAL SEPTUM; CARDIOVASCULAR REGULATION; CHOLINERGIC SYSTEM; 192-IGG SAPORIN; NUCLEUS BASALIS; CELL-TYPES; OXYTOCIN;
Keywords:
arterial baroreceptors; supraoptic nucleus; perinuclear zone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Cunningham, JT Univ Missouri, Dalton Cardiovasc Res Ctr, Res Pk Dr, Columbia, MO 65211 USA Univ Missouri Res Pk Dr Columbia MO USA 65211 MO 65211 USA
Citazione:
R.J. Grindstaff et al., "Baroreceptor sensitivity of rat supraoptic vasopressin neurons involves noncholinergic neurons in the DBB", AM J P-REG, 279(5), 2000, pp. R1934-R1943

Abstract

Previous studies suggest that cholinergic neurons in the diagonal band of Broca (DBB) participate in the baroreceptor-mediated inhibition of phasic vasopressin neurons in the supraoptic nucleus (SON). To test this hypothesis, extracellular recordings were obtained from putative vasopressin SON neurons of anesthetized rats injected with the cholinergic immunotoxin 192 IgG-saporin (0.8 mug/mul) in the DBB. Baroreceptor sensitivity of neurons was tested with brief phenylephrine-induced (10 mug/10 mul iv) increases in blood pressure of at least 40 mmHg. In rats injected with vehicle or unconjugated saporin, 19 of 21 and 18 of 20 phasic neurons, respectively, were inhibited by increased blood pressure. In rats injected with 192 IgG-saporin, which significantly reduced the number of choline acetyltransferase (ChAT)-positive DBB neurons, 33 of 36 phasic neurons were inhibited. Normal rats and rats with DBB saporin injections received rhodamine bead injections into the perinuclear zone (PNZ) to retrogradely label DBB neurons, and their brains were stained for ChAT. ChAT-positive DBB neurons were not retrogradely labeled from the PNZ. Together, these results indicate that the pathway relaying baroreceptor information to the SON involves noncholinergic DBB neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:46:50