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Titolo:
Carotid and aortic baroreflexes of the rat: II. Open-loop frequency response and the blood pressure spectrum
Autore:
Dworkin, BR; Tang, XR; Snyder, AJ; Dworkin, S;
Indirizzi:
Penn State Univ, Coll Med, Dept Behav Sci, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 ept Behav Sci, Hershey, PA 17033 USA Penn State Univ, Coll Med, Neurosci Program, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 rosci Program, Hershey, PA 17033 USA Penn State Univ, Coll Med, Dept Surg, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 ed, Dept Surg, Hershey, PA 17033 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: R1922 - R1933
SICI:
0363-6119(200011)279:5<R1922:CAABOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARORECEPTOR-DENERVATED RATS; HEART-RATE; CONSCIOUS DOGS; SINUS NERVE; ARTERIAL; ULTRASTRUCTURE; CONNECTIONS; MODULATION; MORPHOLOGY; LABILITY;
Keywords:
baroreceptors; carotid sinus; aortic depressor nerve; systems analysis; transfer function; noise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Dworkin, BR Penn State Univ, Coll Med, Dept Behav Sci, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 i, Hershey, PA 17033 USA
Citazione:
B.R. Dworkin et al., "Carotid and aortic baroreflexes of the rat: II. Open-loop frequency response and the blood pressure spectrum", AM J P-REG, 279(5), 2000, pp. R1922-R1933

Abstract

To determine the relationship between blood pressure (BP) variability and the open-loop frequency domain transfer function (TF) of the baroreflexes, we measured the pre- and postsinoaortic denervation (SAD) spectra and the effects of periodic and step inputs to the aortic depressor nerve and isolated carotid sinus of central nervous system-intact, neuromuscular-blocked (NMB) rats. Similar to previous results in freely moving rats, SAD greatly increased very low frequency (VLF) (0.01-0.2 Hz) systolic blood pressure (SBP) noise power. Step response-frequency measurements for SBP; interbeat interval (IBI); venous pressure; mesenteric, femoral, and skin blood flow; and direct modulation analyses of SBP showed that only VLF variability could besubstantially attenuated by an intact baroreflex. The -3-dB frequency for SBP is 0.035-0.056 Hz; femoral vascular conductance is similar to SBP, but mesenteric vascular conductance has a reliably lower and IBI has a reliablyhigher -3-dB point. The overall open-loop transportation lag, of which less than or equal to0.1 s is neural, is approximate to1.07 s. Constrained algebraic solution, over a range of frequencies, of the pre- and postSAD endogenous noise spectra and the independently determined relative frequency andabsolute lag measurements was used to calculate the absolute gain for the open-loop TF. The average gain at 0.02 Hz, the frequency of maximum sensitivity, was 1.47 (95% confidence interval = +/-0.48), which agrees well with estimates for the dog reversible sinus. We found that, in the NMB rat, the effects of SAD on the BP noise spectrum were accounted for by the open-loopproperties of the baroreflex.

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Documento generato il 21/09/20 alle ore 06:39:37