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Titolo:
Carotid and aortic baroreflexes of the rat: I. Open-loop steady-state properties and blood pressure variability
Autore:
Dworkin, BR; Dworkin, S; Tang, XR;
Indirizzi:
Penn State Univ, Coll Med, Dept Behav Sci, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 ept Behav Sci, Hershey, PA 17033 USA Penn State Univ, Coll Med, Neurosci Program, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 rosci Program, Hershey, PA 17033 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: R1910 - R1921
SICI:
0363-6119(200011)279:5<R1910:CAABOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARORECEPTOR-DENERVATED RATS; ARTERIAL-PRESSURE; SINOAORTIC DEAFFERENTATION; PHYSIOLOGICAL-RESPONSES; NERVE-STIMULATION; CONSCIOUS DOGS; REFLEX; CIRCULATION; LABILITY; SINUS;
Keywords:
baroreceptors; aortic depressor nerve; carotid sinus; sinoaortic denervation; noise; baroafferent stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Dworkin, BR Penn State Univ, Coll Med, Dept Behav Sci, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 i, Hershey, PA 17033 USA
Citazione:
B.R. Dworkin et al., "Carotid and aortic baroreflexes of the rat: I. Open-loop steady-state properties and blood pressure variability", AM J P-REG, 279(5), 2000, pp. R1910-R1921

Abstract

To characterize the baroreflex in central nervous system-intact neuromuscular-blocked rats, we measured the vascular and cardiac responses and compared direct stimulation of the aortic depressor nerve (ADN) with a capacitance electrode (differentially activating either A or A + C fibers) to carotidsinus pressure with a micro-balloon (SINUS). One-thousand-two-hundred-ninety-seven open-loop measurements of systolic blood pressure (SBP), heart rate, venous pressure (VBP), and mesenteric (msBF), femoral (fmBF), and skin (skBF) blood flow were completed; the linear range of the effects was determined for each response and stimulus mode. The rats were sinoaortic denervated (SAD). The open-loop stimulation effect was very stable; e.g., the mean effect of 790 ADN stimulations during > 7 days was -9.8 mmHg, with an average drift of +0.001 mmHg/h. In contrast, there was large variability of the SBP baseline (e.g., SD = +/-10.9), which was due to SAD (+/-6.3 to +/- 6.3 mmHg, t = -13.9, df = 4, P < 0.0002) and was reversed by ganglionic block (/-10.8 to +/- 2.9 mmHg, t = -12.9, df = 3, P < 0.001). The ADN stimuli produced larger depressor responses than sinus stimuli (-66 vs. -45 mmHg); allcomponent responses paralleled the magnitude of the SBP effect, except interbeat interval (IBI), for which the ADN Delta IBI was approximate to 10 times that of SINUS. For all stimuli, fmBF increased and msBF did not. Mesenteric and femoral vascular conductance both increased, whereas VBP decreasedand skBF followed SBP. We found that for all baroreflex response components, with the exception of SINUS-elicited Delta IBI, there was an orderly, substantially linear, relationship between stimulus strength and response magnitude.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:18:07