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Titolo:
Sympathetic activity in early renal posttransplantation hypertension in rats
Autore:
Grisk, O; Frey, BAJ; Uber, A; Rettig, R;
Indirizzi:
Univ Greifswald, Dept Physiol, D-17495 Karlsburg, Germany Univ GreifswaldKarlsburg Germany D-17495 ol, D-17495 Karlsburg, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: R1737 - R1744
SICI:
0363-6119(200011)279:5<R1737:SAIERP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROXYLASE MESSENGER-RNA; TYROSINE-HYDROXYLASE; BLOOD-PRESSURE; NERVE ACTIVITY; KIDNEY-TRANSPLANTATION; DAHL RATS; STRESS; EXPRESSION; MECHANISMS; RECIPIENTS;
Keywords:
spontaneously hypertensive rats; renal transplantation; sympathetic nervous system; tyrosine hydroxylase; guanabenz;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Grisk, O Univ Greifswald, Dept Physiol, Greifswalder Str 11C, D-17495 Karlsburg, Germany Univ Greifswald Greifswalder Str 11C Karlsburg Germany D-17495 y
Citazione:
O. Grisk et al., "Sympathetic activity in early renal posttransplantation hypertension in rats", AM J P-REG, 279(5), 2000, pp. R1737-R1744

Abstract

The contribution of elevated sympathetic activity to the development of renal posttransplantation hypertension was investigated. F1 hybrids (F1H) from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) were transplanted with either an SHR or an F1H kidney and bilaterally nephrectomized. Three weeks after transplantation, sympathetic activity was assessed bymeasuring adrenal tyrosine hydroxylase (TH) mRNA content and recording splanchnic nerve activity (SNA) in conscious animals. To investigate the dependence of arterial pressure on sympathetic activity, animals were treated with the alpha (2)-adrenoceptor agonist guanabenz intracerebroventricularly. Mean arterial pressure (MAP) was 143 +/- 4 mmHg in recipients of an SHR kidney (n = 15) versus 110 +/- 3 mmHg in recipients of an F1H kidney (n = 10; P < 0.001). Adrenal TH mRNA content was 1.93 +/- 0.15 fmol/<mu>g total RNA in recipients of an SHR kidney versus 1.96 +/- 0.17 fmol/mg total RNA in recipients of an F1H kidney (not significant). SNA did not differ significantly between recipients of an SHR kidney (n = 8) and recipients of an F1H kidney (n = 7) in terms of frequency and amplitude of synchronized nerve discharges. In response to cumulative intracerebroventricular administration of 10 and 20 mug guanabenz, SNA fell to 51 +/- 5% of control in recipients of an SHR kidney versus 44 +/- 6% of control in recipients of an F1H kidney (not significant) accompanied by a slight fall in MAP in either group. The results suggest that elevated sympathetic activity is not a major contributorto the development of renal posttransplantation hypertension.

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Documento generato il 22/10/20 alle ore 02:50:11