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Titolo:
Assessing baroreflex gain from spontaneous variability in conscious dogs: role of causality and respiration
Autore:
Porta, A; Baselli, G; Rimoldi, O; Malliani, A; Pagani, M;
Indirizzi:
Univ Milan, Dipartimento Sci Preclin, LITA Vialba, I-20157 Milan, Italy Univ Milan Milan Italy I-20157 reclin, LITA Vialba, I-20157 Milan, Italy Univ Milan, CNR, Ctr Ric Cardiovasc, I-20157 Milan, Italy Univ Milan Milan Italy I-20157 Ctr Ric Cardiovasc, I-20157 Milan, Italy Univ Milan, Osped L Sacco, I-20157 Milan, Italy Univ Milan Milan Italy I-20157 ilan, Osped L Sacco, I-20157 Milan, Italy Politecn Milan, Dipartimento Bioingn, I-20133 Milan, Italy Politecn MilanMilan Italy I-20133 timento Bioingn, I-20133 Milan, Italy
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: H2558 - H2567
SICI:
0363-6135(200011)279:5<H2558:ABGFSV>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-RATE; ARTERIAL-PRESSURE; SPECTRAL-ANALYSIS; FLUCTUATIONS; MODEL; IDENTIFICATION; SENSITIVITY; SIGNALS; HUMANS; REFLEX;
Keywords:
cardiovascular variability; linear parametric modeling; identification techniques;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Porta, A Univ Milan, Dipartimento Sci Preclin, LITA Vialba, Via GB Grassi 74, I-20157 Milan, Italy Univ Milan Via GB Grassi 74 Milan Italy I-20157 157 Milan, Italy
Citazione:
A. Porta et al., "Assessing baroreflex gain from spontaneous variability in conscious dogs: role of causality and respiration", AM J P-HEAR, 279(5), 2000, pp. H2558-H2567

Abstract

A double exogenous autoregressive (XXAR) causal parametric model was used to estimate the baroreflex gain (alpha (XXAR)) from spontaneous R-R interval and systolic arterial pressure (SAP) variabilities in conscious dogs. This model takes into account 1) effects of current and past SAP variations onthe R-R interval (i.e., baroreflex-mediated influences), 2) specific perturbations affecting R-R interval independently of baroreflex circuit (e.g., rhythmic neural inputs modulating R-R interval independently of SAP at frequencies slower than respiration), and 3) influences of respiration-related sources acting independently of baroreflex pathway (e.g., rhythmic neural inputs modulating R-R interval independently of SAP at respiratory rate, including the effect of stimulation of low-pressure receptors). Under control conditions, alpha (XXAR) = 14.7 +/- 7.2 ms/mmHg. It decreases after nitroglycerine infusion and coronary artery occlusion, even though the decrease issignificant only after nitroglycerine, and it is completely abolished by total arterial baroreceptor denervation. Moreover, alpha (XXAR) is comparable to or significantly smaller than (depending on the experimental condition) the baroreflex gains derived from sequence, power spectrum [at low frequency (LF) and high frequency (HF)], and cross-spectrum (at LF and HF) analyses and from less complex causal parametric models, thus demonstrating that simpler estimates may be biased by the contemporaneous presence of regulatory mechanisms other than baroreflex mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:22:05