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Titolo:
Preserved ventricular contractility in infarcted mouse heart overexpressing beta(2)-adrenergic receptors
Autore:
Du, XJ; Gao, XM; Jennings, GL; Dart, AM; Woodcock, EA;
Indirizzi:
Baker Med Res Inst, Melbourne, Vic 8008, Australia Baker Med Res Inst Melbourne Vic Australia 8008 urne, Vic 8008, Australia Alfred Hosp, Alfred Heart Ctr, Melbourne, Vic 8008, Australia Alfred HospMelbourne Vic Australia 8008 , Melbourne, Vic 8008, Australia
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: H2456 - H2463
SICI:
0363-6135(200011)279:5<H2456:PVCIIM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-TARGETED MICE; TRANSGENIC MICE; CARDIAC-FUNCTION; FAILURE; EXPRESSION; BLOCKADE; KINASE; HYPERTROPHY; STIMULATION; METOPROLOL;
Keywords:
echocardiography; heart failure; hemodynamics; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Du, XJ Baker Med Res Inst, St Kilda Rd Cent,POB 6492, Melbourne, Vic 8008,Australia Baker Med Res Inst St Kilda Rd Cent,POB 6492 Melbourne Vic Australia 8008
Citazione:
X.J. Du et al., "Preserved ventricular contractility in infarcted mouse heart overexpressing beta(2)-adrenergic receptors", AM J P-HEAR, 279(5), 2000, pp. H2456-H2463

Abstract

Effects of cardiac specific overexpression of beta (2)-adrenergic receptors (beta (2)-AR) on the development of heart failure (HF) were studied in wildtype (WT) and transgenic (TG) mice following myocardial infarction (MI) by coronary artery occlusion. Animals were studied by echocardiography at weeks 7 to 8 and by catheterization at week 9 after surgery. Post-infarct mortality, due to HF or cardiac rupture, was not different among WT mice, and there was no difference in infarct size (IS). Compared with the sham-operated group (all P < 0.01), WT mice with moderate (<36%) and large (>36%) IS developed lung congestion, cardiac hypertrophy, left ventricular (LV) dilatation, elevated LV end-diastolic pressure (LVEDP), and suppressed maximal rate of increase of LV pressure (LV dP/dt(max)) and fractional shortening (FS). Whereas changes in organ weights and echo parameters were similar to those in infarcted WT groups, TG mice had significantly higher levels of LV contractility in both moderate (dP/dt(max) 4,862 +/- 133 vs. 3,694 +/- 191 mmHg/s) and large IS groups (dP/dt(max) 4,556 +/- 252 vs. 3,145 +/- 312 mmHg/s, both P, 0.01). Incidence of pleural effusion (36% vs. 85%, P < 0.05) andLVEDP levels (6 <plus/minus> 0.3 vs. 9 +/- 0.8 mmHg, P < 0.05) were also lower in TG than in WT mice with large IS. Thus <beta>(2)-AR overexpression preserved LV contractility following MI without adverse consequence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:38:10