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Titolo:
Late preconditioning enhances recovery of myocardial function after infarction in conscious rabbits
Autore:
Takano, H; Tang, XL; Kodani, E; Bolli, R;
Indirizzi:
Univ Louisville, Div Cardiol, Expt Res Lab, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Res Lab, Louisville, KY 40292 USA Jewish Hosp, Heart & Lung Inst, Louisville, KY 40292 USA Jewish Hosp Louisville KY USA 40292 & Lung Inst, Louisville, KY 40292 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: H2372 - H2381
SICI:
0363-6135(200011)279:5<H2372:LPEROM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CORONARY-ARTERY REPERFUSION; 2ND WINDOW; LATE-PHASE; SUBLETHAL ISCHEMIA; RAT-HEART; PROTECTION; PROTEIN; OCCLUSION; MECHANISM;
Keywords:
ischemia-reperfusion injury; myocardial infarction; myocardial stunning; S-nitroso-N-acetylpenicillamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bolli, R Univ Louisville, Div Cardiol, Expt Res Lab, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Louisville, KY 40292 USA
Citazione:
H. Takano et al., "Late preconditioning enhances recovery of myocardial function after infarction in conscious rabbits", AM J P-HEAR, 279(5), 2000, pp. H2372-H2381

Abstract

It is unknown whether late preconditioning (PC) enhances the recovery of left ventricular (LV) function after a myocardial infarction. Thus 25 conscious rabbits were subjected to a 30-min coronary occlusion followed by 28 days of reperfusion after PC 24 h earlier with either ischemia or nitric oxide donor administration [S-nitroso-N-acetylpenicillamine (SNAP)]. The recovery of wall thickening (WTh) after reperfusion was significantly improved inthe ischemic PC and SNAP PC groups compared with controls, both at rest and during dobutamine stress. Interestingly, neither ischemia- nor SNAP-induced late PC attenuated myocardial stunning from day 1 through day 14. Infarct size was smaller in the ischemic PC and SNAP PC groups compared with controls. In all groups, WTh at 28 days was positively and linearly related to the percentage of viable tissue in the region underlying the ultrasonic crystal (r = 0.90), indicating that the improvement in LV function after both ischemia-induced and NO donor-induced late PC can be fully explained by thereduction in infarct size; a separate effect of late PC on LV remodeling or LV contractility need not be invoked. In conclusion, in conscious rabbitslate PC, induced either by ischemia or pharmacologically, not only limits infarct size but also enhances the recovery of LV function after myocardialinfarction. This finding has important clinical implications and provides triphenyltetrazolium chloride-independent evidence that late PC limits myocellular death after sustained ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:11:40