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Titolo:
NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury
Autore:
Armstead, WM;
Indirizzi:
Univ Penn, Dept Anesthesia, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 nesthesia, Philadelphia, PA 19104 USA Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 279, anno: 2000,
pagine: H2188 - H2195
SICI:
0363-6135(200011)279:5<H2188:NCTAIO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; OPIOID RECEPTOR FAMILY; K+ CHANNEL FUNCTION; NOCICEPTIN/ORPHANIN FQ; ARTERIOLAR DILATION; RAT; PIGLETS; ACTIVATION; ISCHEMIA; NEWBORN;
Keywords:
newborn; cerebral circulation; opioids; excitatory amino acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Armstead, WM Univ Penn, Dept Anesthesia, 3400 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3400 Spruce St Philadelphia PA USA 19104 19104 USA
Citazione:
W.M. Armstead, "NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury", AM J P-HEAR, 279(5), 2000, pp. H2188-H2195

Abstract

This study characterized the effects of fluid percussion brain injury (FPI) on N-methyl-D-aspartate (NMDA)-induced vasodilation and determined the role of nociceptin/orphanin FQ (NOC/oFQ) in such changes as a function of ageand time postinsult. FPI elevated cerebrospinal fluid (CSF) NOC/oFQ from 70 +/- 3 to 444 +/- 56 pg/ml (approximate to 10(-10) M) within 1 h and to 1,931 +/- 112 pg/ml within 8 h, whereas values returned to control levels within 168 h in the newborn pig. In contrast, FPI elevated CSF NOC/oFQ from 77+/- 4 to 202 +/- 16 pg/ml within 1 h and values returned to control levelswithin 8 h in the juvenile pig. Topical NOC/oFQ (approximate to 10(-10) M)had no effect on pial artery diameter but attenuated NMDA (10(-8), 10(-6) M)-induced dilation (9 +/- 1 and 16 +/- 1 vs. 5 +/- 1 and 10 +/- 1%) in both age groups. In the newborn, NMDA-induced pial artery dilation was reversed to vasoconstriction within 1 h post-FPI and responses remained impaired for 72 h, but such vasoconstriction was attenuated by pretreatment with [F/G]NOC/oFQ(1-13)-NH2 (10(-6) M, 1 mg/kg iv), an NOC/oFQ antagonist (9 +/- 1 and 16 +/- 1 vs. -7 +/- 1 and -12 +/- 1 vs -2 +/- 1 and -3 +/- 1% for control, FPI, and FPI pretreated with the NOC/oFQ antagonist). In contrast, in the juvenile, NMDA-induced vasodilation was only attenuated within 1 h post-FPI and returned to control within 8 h. Such dilation was also partially restored by the NOC/oFQ antagonist. These data indicate that NOC/oFQ contributes to impaired NMDA pial artery dilation after FPI. These data suggest thatthe greater NOC/oFQ release in the newborn versus the juvenile may contribute to age-related differences in FPI effects on excitatory amino acid-induced pial dilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:17:18