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Titolo:
Lumped constant for [F-18] fluorodeoxyglucose in skeletal muscles of obeseand nonobese humans
Autore:
Peltoniemi, P; Lonnroth, P; Laine, H; Oikonen, V; Tolvanen, T; Gronroos, T; Strindberg, L; Knuuti, J; Nuutila, P;
Indirizzi:
Univ Turku, Turku PET Ctr, Dept Med, F-20520 Turku, Finland Univ Turku Turku Finland F-20520 T Ctr, Dept Med, F-20520 Turku, Finland Univ Gothenburg, Dept Internal Med, Lundberg Lab Diabet Res, S-41345 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-41345 es, S-41345 Gothenburg, Sweden Univ Gothenburg, Turku Positron Emiss Tomog Ctr, S-41345 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden S-41345 tr, S-41345 Gothenburg, Sweden
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 5, volume: 279, anno: 2000,
pagine: E1122 - E1130
SICI:
0193-1849(200011)279:5<E1122:LCF[FI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATED GLUCOSE-UPTAKE; BRAIN TRANSFER CONSTANTS; TIME UPTAKE DATA; INSULIN-RESISTANCE; BLOOD-FLOW; ESSENTIAL-HYPERTENSION; GRAPHICAL EVALUATION; EMISSION TOMOGRAPHY; ADIPOSE-TISSUE; HEART;
Keywords:
glucose transport; glucose phosphorylation; insulin resistance; microdialysis; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Peltoniemi, P Univ Turku, Turku PET Ctr, Dept Med, POB 52, F-20520 Turku, Finland Univ Turku POB 52 Turku Finland F-20520 0520 Turku, Finland
Citazione:
P. Peltoniemi et al., "Lumped constant for [F-18] fluorodeoxyglucose in skeletal muscles of obeseand nonobese humans", AM J P-ENDO, 279(5), 2000, pp. E1122-E1130

Abstract

Quantitative 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG) positron emission tomography (PET) has been widely used to calculate glucose utilization inskeletal muscle. FDG-PET results depend partly on the lumped constant (LC), which accounts for the differences in the transport and phosphorylation between [F-18]FDG and glucose. In this study, we estimated the LC for [F-18]FDG directly in normal and in insulin-resistant obese subjects by combiningFDG PET with the microdialysis technique. Eight obese [age 29.4 +/- 1.0 yr, body mass index (BMI) 33.6 +/- 1.0 kg/m(2)] and eight nonobese (age 25.0 /- 1.0 yr, BMI 23.1 +/- 1.0 kg/m(2)) males were studied during euglycemic hyperinsulinemia (1 mU.kg(-1).min(-1) for 150 min). Muscle blood flow was measured using O-15-labeled water and PET. Muscle [F-18]FDG uptake (rGU(FDG)) was calculated with Patlak graphic analysis. Interstitial glucose concentration of the quadriceps femoris muscle was measured simultaneously with [F-18]FDG scanning using microdialysis. Muscle glucose uptake (by microdialysis, rGU(MD)) was calculated by multiplying glucose extraction by regional muscle blood flow. A significant correlation was found between rGU(MD) and rGU(FDG) (r = 0.78, P < 0.01). The LC was determined as the ratio of the rGU(FDG) to the rGU(MD). The LC averaged 1.16 +/- 0.16 and was similar in the obese and nonobese subjects (1.15 +/- 0.11 vs. 1.16 +/- 0.07, respectively,not significant). In conclusion, the microdialysis technique can be reliably combined with FDG PET to measure glucose uptake in skeletal muscle. Direct measurements with these two independent techniques suggest an LC value of 1.2 for [F-18]FDG in human skeletal muscle during insulin stimulation, and the LC appears not to be sensitive to insulin resistance.

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Documento generato il 20/01/20 alle ore 16:22:27