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Titolo:
Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production
Autore:
Chirieac, DV; Chirieac, LR; Corsetti, JP; Cianci, J; Sparks, CE; Sparks, JD;
Indirizzi:
Univ Rochester, Sch Med & Dent, Dept Pathol & Lab Med, Rochester, NY 14642USA Univ Rochester Rochester NY USA 14642 l & Lab Med, Rochester, NY 14642USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 5, volume: 279, anno: 2000,
pagine: E1003 - E1011
SICI:
0193-1849(200011)279:5<E1003:GISSHT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; CULTURED RAT HEPATOCYTES; APOLIPOPROTEIN-B SECRETION; ACUTE HYPERINSULINEMIA; FATTY-ACIDS; ENDOPLASMIC-RETICULUM; PLASMA-LIPOPROTEINS; LIVER; TRIACYLGLYCEROL; METABOLISM;
Keywords:
lipoprotein secretion by liver; very low density lipoprotein; Triton WR-1339 treatment; in vivo apolipoprotein B production;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Sparks, JD Univ Rochester, Sch Med & Dent, Dept Pathol & Lab Med, Box 626,601 ElmwoodAve, Rochester, NY 14642 USA Univ Rochester Box 626,601 Elmwood Ave Rochester NY USA 14642 A
Citazione:
D.V. Chirieac et al., "Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production", AM J P-ENDO, 279(5), 2000, pp. E1003-E1011

Abstract

The current study assessed in vivo the effect of insulin on triglyceride-rich lipoprotein (TRL) production by rat liver. Hepatic triglyceride and apolipoprotein B (apoB) production were measured in anesthetized, fasted rats injected intravenously with Triton WR-1339 (400 mg/kg). After intravascularcatabolism was blocked by detergent treatment, glucose (500 mg/kg) was injected to elicit insulin secretion, and serum triglyceride and apoB accumulation were monitored over the next 3 h. In glucose-injected rats, triglyceride secretion averaged 22.5 +/- 2.1 mug.ml(-1).min(-1), which was significantly less by 30% than that observed in saline-injected rats, which averaged 32.1 +/- 1.4 mug.ml(-1)min(-1). ApoB secretion was also significantly reduced by 66% in glucose-injected rats. ApoB immunoblotting indicated that bothB100 and B48 production were significantly reduced after glucose injection. Results support the conclusion that insulin acts in vivo to suppress hepatic very low density lipoprotein (VLDL) triglyceride and apoB secretion andstrengthen the concept of a regulatory role for insulin in VLDL metabolismpostprandially.

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Documento generato il 29/03/20 alle ore 10:13:28