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Titolo:
Spontaneous firing activity of cortical neurons in adult cats with reorganized tonotopic map following pure-tone trauma
Autore:
Komiya, H; Eggermont, JJ;
Indirizzi:
Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 ychol, Calgary, AB T2N 1N4, Canada Univ Calgary, Dept Physiol & Biophys, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 ophys, Calgary, AB T2N 1N4, Canada
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 6, volume: 120, anno: 2000,
pagine: 750 - 756
SICI:
0001-6489(200009)120:6<750:SFAOCN>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY AUDITORY-CORTEX; INFERIOR COLLICULUS NEURONS; PARTIAL COCHLEAR LESIONS; RESPONSE PROPERTIES; NEURAL ACTIVITY; HEARING-LOSS; THRESHOLD SHIFT; C57BL/6J MICE; SALICYLATE; PLASTICITY;
Keywords:
burst firing; cross-correlation; primary auditory cortex; pure-tone trauma; spontaneous firing rate; tonotopic map;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Eggermont, JJ Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N1N4, Canada Univ Calgary 2500 Univ Dr NW Calgary AB Canada T2N 1N4 anada
Citazione:
H. Komiya e J.J. Eggermont, "Spontaneous firing activity of cortical neurons in adult cats with reorganized tonotopic map following pure-tone trauma", ACT OTO-LAR, 120(6), 2000, pp. 750-756

Abstract

We hypothesized that moderate sensorineural hearing loss resulting from acoustic trauma would cause (i) a change in the cortical tonotopic map, (ii) an increase in spontaneous activity in the reorganized region and (iii) increased inter-neuronal synchrony within the reorganized part of the cortex. Five kittens were exposed to a 126 dB sound pressure limit tone of 6 kHz for 1 h at both 5 and 6 weeks of age. Recordings were performed 7-16 weeks after the exposure. Auditory brainstem response thresholds for frequencies above 12 kHz were increased by 30 dB on average relative to those in normal cats. Tonotopic maps in the primary auditory cortex were reorganized in sucha way that the area normally tuned to frequencies of 10-40 kHz was now entirely tuned to 10 kHz. Spontaneous firing rates were significantly higher in reorganized areas than in normal areas. In order to test for changes in inter-neuronal synchrony, cross-correlation analysis was done on 225 single-unit pairs recorded in the traumatized cats. For the single- and dual-electrode pairs there was no significant difference in peak cross-correlation coefficients for the firings of simultaneously recorded cells between normal and reorganized areas. However, the percentage of correlations that differed significantly from zero was higher in the reorganized area than in the normal area. This suggests a potential correlation between cortical reorganization, increased spontaneous firing rare and inter-neuronal synchrony that might be related to tinnitus found in high-frequency hearing loss induced by acoustic trauma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:34:12