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Titolo:
Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system
Autore:
Nally, JE; Artiushin, S; Sheoran, AS; Burns, PJ; Simon, B; Gilley, RM; Gibson, J; Sullivan, S; Timoney, JF;
Indirizzi:
Univ Kentucky, Maxwell H Gluck Equine Res Ctr 108, Lexington, KY 40546 USAUniv Kentucky Lexington KY USA 40546 Res Ctr 108, Lexington, KY 40546 USA Thorn Biosci LLC, Lexington, KY USA Thorn Biosci LLC Lexington KY USAThorn Biosci LLC, Lexington, KY USA So Biosyst Inc, Birmingham, AL USA So Biosyst Inc Birmingham AL USASo Biosyst Inc, Birmingham, AL USA
Titolo Testata:
VACCINE
fascicolo: 4-5, volume: 19, anno: 2000,
pagine: 492 - 497
SICI:
0264-410X(20001015)19:4-5<492:IOMASA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; SUBSP EQUI; M-PROTEIN; RESPONSES; INFECTION; HORSES; SERUM;
Keywords:
intranasal immunization; sucrose acetate isobutyrate; equine immunoglobulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Timoney, JF Univ Kentucky, Maxwell H Gluck Equine Res Ctr 108, Lexington, KY 40546 USA Univ Kentucky Lexington KY USA 40546 Lexington, KY 40546 USA
Citazione:
J.E. Nally et al., "Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system", VACCINE, 19(4-5), 2000, pp. 492-497

Abstract

Streptococcus equi causes equine strangles, a highly contagious disease ofthe upper respiratory tract. The antiphagocytic surface protein SeM is strongly immunogenic and evokes mucosal and systemic antibodies during convalescence. The present study investigated the potential of sucrose acetate isobutyrate (SAIB); a high viscosity excipient that provides controlled release of biologically active substances, to enhance antibody responses following intranasal immunization of horses with a 108 a.a. peptide of SeM (SeMF3). SeMF3-SAIB was administered intranasally to each of the 11 adult horses ondays 0 and 28, A second group of seven horses was vaccinated with SeMF3 alone. SAIB enhanced the mucosal and systemic immunogenicity of SeMF3, whereas SeMF3 by itself stimulated only a shortlived mucosal IgA and no systemic response. Moreover, nasal mucosal responses of horses immunized with SeMF3-SAIB were qualitatively and quantitatively similar to those observed in convalescent horses and involved similar linear epitopes of SeM. Epitope analysis also suggested that the nasal response was different from that observedin serum. A booster response was obtained after the second vaccination. These results suggest that SAIB has potential as a vehicle for intranasal immunization of horses with antigenic peptides. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 01:10:24