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Titolo:
Effect of aluminum on delta-aminolevulinic acid dehydratase from mouse blood
Autore:
Vieira, VLP; Rocha, JBT; Schetinger, MRC; Morsch, VM; Rodrigues, SR; Tuerlinckz, SM; Bohrer, D; do Nascimento, PC;
Indirizzi:
Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil Univ Fed Santa Maria Santa Maria RS Brazil BR-97105900 BCaria, RS, Brazil
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-2, volume: 117, anno: 2000,
pagine: 45 - 52
SICI:
0378-4274(20000930)117:1-2<45:EOAODA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTNATAL BRAIN GROWTH; ESSENTIAL THIOL-GROUPS; PORPHOBILINOGEN SYNTHASE; SUCKLING RATS; 2ND STAGE; ZINC; ABSORPTION; EXPOSURE; LEAD; INHIBITION;
Keywords:
plasma and blood aluminum disposition; citrate; delta-aminolevulinic acid dehydratase (ALA-D);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Schetinger, MRC Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil Univ Fed Santa Maria Santa Maria RS Brazil BR-97105900 BC
Citazione:
V.L.P. Vieira et al., "Effect of aluminum on delta-aminolevulinic acid dehydratase from mouse blood", TOX LETT, 117(1-2), 2000, pp. 45-52

Abstract

The objective of this study was to investigate aluminum deposition in whole blood and plasma of mice and the activity of blood 6-aminolevulinic acid dehydratase (ALA-D) after in vitro and in vivo exposure to this element. Invitro experiments showed activation and inhibition of the enzyme activity when 0.01-5.0 mM of aluminum sulphate were used (IC50: 1.31 mM). Treatment with citrate and aluminum plus citrate increased ALA-D activity in vivo andthe increase in enzyme activity was parallel to the increase in aluminum content in blood and plasma. These results show that aluminum has a distincteffect on ALA-D activity: first, at relatively lower concentrations it activated, and at high concentration it inhibited, blood ALA-D in vitro; second, it activated the enzyme when administered to drinking water. One important toxicological finding of the present report is that the apparent irrelevant addition of citrate to the drinking water significantly increased the level of aluminum in blood and plasma. Thus, in order to predict more accurately the extent of human exposure to aluminum it would be advantageous to consider the level of citrate ingestion and not exclusively the aluminum level in water or food. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:04:40