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Titolo:
Sensitization of CD4(+) T cells to coagulation factor VIII: Response in congenital and acquired hemophilia patients and in healthy subjects
Autore:
Reding, MT; Wu, HY; Krampf, M; Okita, DK; Diethelm-Okita, BM; Christie, BA; Key, NS; Conti-Fine, BM;
Indirizzi:
Univ Minnesota, Dept Biochem Mol Biol & Biophys, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Biol & Biophys, St Paul, MN 55108 USA Univ Minnesota, Dept Med, St Paul, MN 55108 USA Univ Minnesota St Paul MNUSA 55108 sota, Dept Med, St Paul, MN 55108 USA Univ Minnesota, Dept Pharmacol, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Dept Pharmacol, St Paul, MN 55108 USA
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 4, volume: 84, anno: 2000,
pagine: 643 - 652
SICI:
0340-6245(200010)84:4<643:SOCTCT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE ACETYLCHOLINE-RECEPTOR; EXPERIMENTAL MYASTHENIA-GRAVIS; ANTI-FACTOR-VIII; EPITOPE SEQUENCES; CRYSTAL-STRUCTURE; A PATIENTS; ANTIBODIES; INHIBITORS; SPECIFICITY; RECOGNITION;
Keywords:
immune response; T cells; factor VIII; inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Conti-Fine, BM Univ Minnesota, Dept Biochem Mol Biol & Biophys, 1479 Gortner Ave, St Paul, MN 55108 USA Univ Minnesota 1479 Gortner Ave St Paul MN USA 55108 08 USA
Citazione:
M.T. Reding et al., "Sensitization of CD4(+) T cells to coagulation factor VIII: Response in congenital and acquired hemophilia patients and in healthy subjects", THROMB HAEM, 84(4), 2000, pp. 643-652

Abstract

Antibodies (Ab) that inhibit factor VIII (fVIII) may develop in patients with hemophilia A and rarely in individuals without congenital fVIII deficiency (acquired hemophilia). Synthesis of fVIII inhibitors requires CD4(+) T cells. We investigated the proliferative response of blood CD4(+) cells from 11 patients with congenital or acquired hemophilia and 12 healthy subjects, to recombinant human fVIII, and to pools of overlapping synthetic peptides spanning the sequences of individual fVIII domains. All patients had CD4(+) cells that responded to fVIII. The intensity of the responses fluctuated over time: several patients had brief periods when they did not respond to fVIII. All healthy subjects had transient CD4(+) responses to fVIII that were significantly lower than those of hemophilia patients. Also, healthy subjects responded to fVIII less frequently and for shorter periods than hemophilia patients. All patients and healthy subjects recognized several fVIII domains: the A3 domain was recognized most strongly and frequently. The transient sensitization of CD4(+) cells to fVIII in healthy subjects suggests that inadequate tolerization of CD4(+) cells to fVIII, due to lack of endogenous fVIII, is an important factor in the development of clinically significant anti-fVIII antibodies in hemophilia A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 08:17:12