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Titolo:
Nicotine effects on regional cerebral blood flow in awake, resting tobaccosmokers
Autore:
Domino, EF; Minoshima, S; Guthrie, S; Ohl, L; Ni, LS; Koeppe, RA; Zubieta, JK;
Indirizzi:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Internal Med Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ed Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Coll Pharm, Ann Arbor, MI 48109 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA , Mental Hlth Res Inst, Ann Arbor, MI USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 38, anno: 2000,
pagine: 313 - 321
SICI:
0887-4476(200012)38:3<313:NEORCB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE; NONSMOKERS; PLASMA; BRAIN;
Keywords:
nicotine; cerebral blood flow; awake; resting; tobacco smokers; oxygen 15 water;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Domino, EF Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 , Ann Arbor, MI 48109 USA
Citazione:
E.F. Domino et al., "Nicotine effects on regional cerebral blood flow in awake, resting tobaccosmokers", SYNAPSE, 38(3), 2000, pp. 313-321

Abstract

The hypothesis for this research was that regional cerebral blood flow (rCBF) would increase following nasal nicotine administration to overnight abstinent tobacco smokers in relationship to the known brain distribution of nicotinic cholinergic receptors (nAChRs). Nine male and nine female healthy adult smokers were studied. They abstained overnight from tobacco products for 10 or more hours prior to study the next morning. Nicotine nasal spray was given in doses of 1-2.5 mg total with half in each nostril while the subject was awake and resting in a supine position. Oleoresin of pepper solution in a similar volume was used as an active placebo to control for the irritating effects of nicotine. Both substances were given single blind to the subjects. Positron emission tomography (PET) with (H2O)-O-15 was used to measure rCBF. The data from each subject volunteer were normalized to global activity to better assess regional brain changes. Both nasal nicotine andpepper spray produced similar increases in CBF in somesthetic area II, consistent with the irritant effects of both substances. The mean rCBF effectsof nasal pepper were subtracted from those of nasal nicotine to determine the actions of nicotine alone. The latter produced increases in rCBF in thethalamus, pens, Brodman area 17 of the visual cortex, and cerebellum. Somebrain areas that contain a large number of nAChRs, such as the thalamus, showed an increase in CBF. Other areas that have few nAChRs, such as the cerebellum, also showed an increase in relative CBF. The hippocampal/parahippocampal areas showed greater regional decreases (left) and lesser increases (right) in CBF that correlated with the increase in plasma arterial nicotine concentrations. The results obtained indicate complex primary and secondary effects of nicotine in which only some regional brain CBF changes correlate with the known distribution of nAChR. No gender differences were noted. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:16:22