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Titolo:
Behavioural effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate-receptor antagonists and their relevance to substance abuse
Autore:
Jackson, A; Mead, AN; Stephens, DN;
Indirizzi:
Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England Univ Sussex Brighton E Sussex England BN1 9QG BN1 9QG, E Sussex, England NIDA, Behav Neurosci Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 ral Res Program, NIH, Baltimore, MD 21224 USA
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 1, volume: 88, anno: 2000,
pagine: 59 - 76
SICI:
0163-7258(200010)88:1<59:BEOA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; EXCITATORY AMINO-ACIDS; VENTRAL TEGMENTAL AREA; AMPA RECEPTOR ANTAGONIST; RAT NUCLEUS-ACCUMBENS; D-ASPARTATE RECEPTORS; AMPHETAMINE ADMINISTRATION ALTERS; INDUCED LOCOMOTOR-ACTIVITY; LOCUS-COERULEUS NEURONS; NMDA RECEPTOR;
Keywords:
AMPA receptors; NMDA receptors; substance abuse; plasticity; sensitisation; conditioning;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
182
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, A Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England Univ Sussex Brighton E Sussex England BN1 9QG Sussex, England
Citazione:
A. Jackson et al., "Behavioural effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate-receptor antagonists and their relevance to substance abuse", PHARM THERA, 88(1), 2000, pp. 59-76

Abstract

This review presents some of the work that has been carried out to investigate the behavioural effects of alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-receptor antagonists in animal models of substance abuse,Many of the studies have been conducted in light of current ideas that emphasise the analogous role of glutamatergic mechanisms in synaptic plasticity and long-term behavioural adaptation to drugs. Experiments on behaviouralsensitisation indicate that whereas N-methyl-D-aspartate receptors are involved in induction, AMPA-receptors may mediate expression of the established response. In this regard, an important factor may be the degree of drug-environment conditioning. Thus, studies of the effects of AMPA-receptor antagonists on conditioned behaviours are reviewed here, Relatively few studieson the effects of AMPA-receptor antagonists on primary reinforcement from self-administered drugs and the subjective effects of drugs have been carried out, but a profile that contrasts with that of the N-methyl-D-aspartate antagonists appears to be emerging. Studies of withdrawal from opioids suggest that whilst AMPA-receptor antagonists may not be able to prevent tolerance or dependence from developing, they may ameliorate both the physical and emotional consequences of withdrawal. Overall, the AMPA-receptor antagonists may represent a promising new approach for treating the consequences ofdrug abuse. However, as results are often complicated by the use of the less-selective compounds, it will be important to use better tools in future studies. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:23:08