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Titolo:
The contribution of the adriamycin-induced rat model of the VATER association to our understanding of congenital abnormalities and their embryogenesis
Autore:
Beasley, SW; Pardo, JD; Qi, BQ; Tovar, JA; Xia, HM;
Indirizzi:
Christchurch Hosp, Dept Paediat Surg, Christchurch, New Zealand Christchurch Hosp Christchurch New Zealand g, Christchurch, New Zealand
Titolo Testata:
PEDIATRIC SURGERY INTERNATIONAL
fascicolo: 7, volume: 16, anno: 2000,
pagine: 465 - 472
SICI:
0179-0358(200009)16:7<465:TCOTAR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTAL TRACHEOESOPHAGEAL FISTULA; RODENT EXPERIMENTAL-MODEL; PROGRAMMED CELL-DEATH; ESOPHAGEAL ATRESIA; CARDIOVASCULAR MALFORMATIONS; TRACHEAL AGENESIS; FOREGUT MALFORMATIONS; VERTEBRAL ANOMALIES; HUMAN-EMBRYOS; FETAL RATS;
Keywords:
adriamycin; apoptosis; embryogenesis; esophageal atresia; notochord; VATER association;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Beasley, SW Christchurch Hosp, Dept Paediat Surg, Private Bag 4710, Christchurch, New Zealand Christchurch Hosp Private Bag 4710 Christchurch New Zealand
Citazione:
S.W. Beasley et al., "The contribution of the adriamycin-induced rat model of the VATER association to our understanding of congenital abnormalities and their embryogenesis", PEDIAT SURG, 16(7), 2000, pp. 465-472

Abstract

The adriamycin-induced rat model of the VATER association has provided a means of studying the morphogenesis of a variety of major congenital structural abnormalities similar to those seen in humans with the VATER association. Most interest has been centered on the foregut, where the model has clarified some aspects of the development of esophageal atresia (EA), tracheal agenesis, and other communicating bronchopulmonary foregut malformations. It has demonstrated aberrations in the nerve supply to the esophagus in EA and allowed the study of tracheomalacia. A relationship between an abnormal notochord, foregut abnormalities, and vertebral defects has been shown, andthe model has reignited interest in the role of the notochord as a regional organizer of axial development. The normal temporospatial characteristicsof apoptosis during fore- and hindgut development is disturbed in this model, resulting in abnormal morphology. The indications are that this model will continue to clarify the processes that lead to many of the structural congenital abnormalities that are seen in infants born with the VATER association.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:11:04