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Titolo:
Grading of cerebral autoregulation in preterm and term neonates
Autore:
Verma, PK; Panerai, RB; Rennie, JM; Evans, DH;
Indirizzi:
Univ Leicester, Leicester Royal Infirm, Fac Med, Dept Med Phys,Div Med Phys, Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW er LE1 5WW, Leics, England Univ London Kings Coll Hosp, Neonatal Unit, London, England Univ London Kings Coll Hosp London England onatal Unit, London, England
Titolo Testata:
PEDIATRIC NEUROLOGY
fascicolo: 3, volume: 23, anno: 2000,
pagine: 236 - 242
SICI:
0887-8994(200009)23:3<236:GOCAIP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW AUTOREGULATION; DOPPLER ULTRASOUND; CAROTID-ARTERY; INTRAVENTRICULAR HEMORRHAGE; PREMATURE NEWBORNS; AUTO-REGULATION; INFANTS; DYNAMICS; PRESSURE; VELOCITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Panerai, RB Univ Leicester, Leicester Royal Infirm, Fac Med, Dept Med Phys,Div Med Phys, Leicester LE1 5WW, Leics, England Univ Leicester Leicester Leics England LE1 5WW Leics, England
Citazione:
P.K. Verma et al., "Grading of cerebral autoregulation in preterm and term neonates", PED NEUROL, 23(3), 2000, pp. 236-242

Abstract

The response of cerebral blood flow velocity to a single spontaneous transient rise in blood pressure was studied to grade the cerebral autoregulatory response of newborns. Blood pressure was measured continuously through anumbilical or peripheral arterial catheter; continuous flow velocity recordings were taken from the middle cerebral artery using continuous wave Doppler ultrasound. From a cohort of 62 healthy term and preterm neonates, 325 transients in mean arterial blood pressure and mean cerebral blood flow velocity were identified for analysis using a foot-seeking algorithm. An initial classification of active or impaired autoregulation was given to each transient using a self-clustering technique. The grading of the transients wasstudied by examining the slope of the return of the cerebral blood flow velocity to baseline. Negative slopes indicate a normal autoregulation; slopes of 0 or greater indicate an absence of autoregulation. This classification was in agreement with the self-clustering method (Cohen's kappa = 0.94, P< 0.0001). The relationship between the autoregulatory response assessed by the grading method and gestational age, postnatal age, and Pco(2) was examined using linear regression analysis. A significant relationship with gestational age (P = 0.002) but not Pco(2) (P = 0.06) or postnatal age (P = 0.14) was evident. (C) 2000 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:24:46