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Titolo:
A case of cytophagic histiocytic panniculitis associated with exertional rhabdomyolysis
Autore:
Kanai, Y; Iwaya, K; Kuroda, M; Harada, M; Hirata, F; Mukai, K;
Indirizzi:
Tokyo Med Univ, Dept Pathol 1, Shinjuku Ku, Tokyo 1608402, Japan Tokyo MedUniv Tokyo Japan 1608402 1, Shinjuku Ku, Tokyo 1608402, Japan Self Def Force Hosp Yokosuka, Dept Internal Med, Kanagawa, Japan Self Def Force Hosp Yokosuka Kanagawa Japan ternal Med, Kanagawa, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 10, volume: 50, anno: 2000,
pagine: 858 - 862
SICI:
1320-5463(200010)50:10<858:ACOCHP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; FAS LIGAND EXPRESSION; HEMOPHAGOCYTIC SYNDROME; HEMORRHAGIC DIATHESIS; SJOGRENS-SYNDROME; KILLER-CELL; LYMPHOMA; SERUM; TUMOR; TRANSPLANTATION;
Keywords:
cytophagic histiocytic panniculitis; exertional rhabdomyolysis; Fas/FasL system; steroid pulse therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mukai, K Tokyo Med Univ, Dept Pathol 1, Shinjuku Ku, Shinjuku 6-1-1, Tokyo1608402,Japan Tokyo Med Univ Shinjuku 6-1-1 Tokyo Japan 1608402 1608402,Japan
Citazione:
Y. Kanai et al., "A case of cytophagic histiocytic panniculitis associated with exertional rhabdomyolysis", PATHOL INT, 50(10), 2000, pp. 858-862

Abstract

An 18-year-old man who suffered from panniculitis involving the entire left lower limb after exertional rhabdomyolysis is reported. A high fever (> 39 degreesC) and leukocytosis (> 20 000/muL) persisted for 1 week, and his general status deteriorated rapidly into pre-disseminated intravascular coagulation, complicated by pleural effusion and prolonged clotting time. His condition was dramatically improved by steroid pulse therapy and he has remained in good health for the 20 months since discharge. Histologic examination of subcutaneous tissue from the swollen left lower limb revealed pleomorphic small, medium or large lymphocytes, macrophages and neutrophils infiltrating the edematous subcutaneous adipose tissue in a lobular panniculitis-like pattern. The majority of inflammatory cells were T lymphocytes, with equal proportions of CD4+ and CD8+ cells. As polymerase chain reaction did not show bands suggesting T cell receptor gamma gene rearrangement, the proliferation of T lymphocytes was considered to be polyclonal. The T lymphocytes also expressed Fas ligand, suggesting the involvement of Fas-mediated cytotoxicity. This case may represent a new category of cytophagic histiocytic panniculitis induced by exertional rhabdomyolysis.

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Documento generato il 01/12/20 alle ore 01:16:25