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Titolo:
Insulin sensitivity after a reduced-fat diet and a monoene-enriched diet in subjects with elevated serum cholesterol and triglyceride concentrations
Autore:
Louheranta, AM; Schwab, US; Sarkkinen, ES; Voutilainen, ET; Ebeling, TML; Erkkila, AT; Turpeinen, AK; Uusitupa, MIJ;
Indirizzi:
Univ Kuopio, Dept Clin Nutr, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 lin Nutr, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Internal Med, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 rnal Med, FIN-70211 Kuopio, Finland Univ Oulu, Dept Internal Med, SF-90220 Oulu, Finland Univ Oulu Oulu Finland SF-90220 ept Internal Med, SF-90220 Oulu, Finland
Titolo Testata:
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
fascicolo: 4, volume: 10, anno: 2000,
pagine: 177 - 187
SICI:
0939-4753(200008)10:4<177:ISAARD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; IMPAIRED GLUCOSE-TOLERANCE; LOW-CARBOHYDRATE DIET; HEALTHY-YOUNG WOMEN; HIGH-FIBER DIET; BLOOD-LIPIDS; MUSCLE TRIGLYCERIDE; HEART-DISEASE; PALMITIC ACID; FACTOR-VII;
Keywords:
insulin sensitivity; serum triglyceride; serum cholesterol; monounsaturated fat; diet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Louheranta, AM Univ Kuopio, Dept Clin Nutr, Harjulantie 1, FIN-70211 Kuopio, Finland Univ Kuopio Harjulantie 1 Kuopio Finland FIN-70211 Finland
Citazione:
A.M. Louheranta et al., "Insulin sensitivity after a reduced-fat diet and a monoene-enriched diet in subjects with elevated serum cholesterol and triglyceride concentrations", NUTR MET CA, 10(4), 2000, pp. 177-187

Abstract

Background and Aims: To investigate the effect of a reduced-fat diet and amonoene-enriched diet (MUFA diet) on serum lipids, glucose and insulin metabolism in subjects with elevated cholesterol and triglyceride concentrations. Methods and Results: Eighteen subjects with elevated serum cholesterol andtriglyceride concentrations consumed the MUFA diet (39% of energy (E%) as fat and 21 E% monoenes) and the reduced-fat diet (34 E% fat, 16 E% monoenes) for 4 weeks according to a randomized cross-over design. Both periods were preceded by consumption of a standardized baseline diet for 2 weeks. Serum lipid and lipoprotein concentrations were determined at the beginning andend of each diet period. A frequently sampled intravenous glucose tolerance test was performed after the MUFA diet and the reduced-fat diet. Insulin sensitivity index (S-I) was 40% higher after the reduced-fat diet than after the MUFA diet (2.42+/-0.42 vs. 1.73+/-0.24 10(-4) min(-1) U-1 ml(-1), p=0.018). This change in insulin sensitivity was seen in 13 subjects and was most evident in those who began with the MUFA diet. Compared to the baselinediet (high in saturated fat), both experimental diets lowered serum total and LDL cholesterol concentrations (6.6-6.9%, p<0.05 and 7.4-8.0%, p<0.95 respectively). Conclusions: Both diets were equally effective in lowering serum lipid concentrations, but the reduced-fat diet resulted in better insulin sensitivity. Nutr Metab Cardiovasc Dis (2000) 10:177-187 (C) 2000, Medikal Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:55:27