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Titolo:
Nitric oxide involvement in Drosophila immunity
Autore:
Nappi, AJ; Vass, E; Frey, F; Carton, Y;
Indirizzi:
Loyola Univ, Dept Biol, Chicago, IL 60626 USA Loyola Univ Chicago IL USA 60626 a Univ, Dept Biol, Chicago, IL 60626 USA CNRS, Lab Populat Genet & Evolut, F-91198 Gif Sur Yvette, France CNRS GifSur Yvette France F-91198 volut, F-91198 Gif Sur Yvette, France
Titolo Testata:
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
fascicolo: 4, volume: 4, anno: 2000,
pagine: 423 - 430
SICI:
1089-8603(200008)4:4<423:NOIIDI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; TRANSCRIPTION FACTOR; HYDROGEN-PEROXIDE; ANTIMICROBIAL PEPTIDES; HOST-DEFENSE; ACTIVATION; SUPEROXIDE; GENE; MESSENGERS; GENERATION;
Keywords:
nitric oxide; Drosophila; immunity; reactive oxygen species; reactive nitrogen species;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Nappi, AJ Loyola Univ, Dept Biol, Chicago, IL 60626 USA Loyola Univ Chicago IL USA 60626 pt Biol, Chicago, IL 60626 USA
Citazione:
A.J. Nappi et al., "Nitric oxide involvement in Drosophila immunity", NITRIC OXID, 4(4), 2000, pp. 423-430

Abstract

The augmented production of nitric oxide (NO) was observed during the hemocyte-mediated melanotic encapsulation responses of Drosophila melanogaster and D. teissieri. When introduced into the hemocoel of D. melanogaster larvae, NO activated the gene encoding the antimicrobial peptide Diptericin. These observations, together with previous studies documenting the productionof superoxide anion (O-2(.-)) and H2O2 in immune-challenged Drosophila, provide evidence that reactive intermediates of both oxygen (ROI) and nitrogen (RNI) constitute a part of the cytotoxic arsenal employed by Drosophila in defense against both microbial pathogens and eukaryotic parasites. These ROI and RNI appear to represent an evolutionarily conserved innate immune response that is mediated by regulatory proteins that are homologous to those of mammalian species. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:27:17