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Titolo:
COX-2 inhibitors
Autore:
Brooks, PM; Day, RO;
Indirizzi:
Univ Queensland, Royal Brisbane Hosp, Fac Hlth Sci, Herston, Qld 4029, Australia Univ Queensland Herston Qld Australia 4029 , Herston, Qld 4029, Australia Univ New S Wales, St Vincents Hosp, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia cents Hosp, Sydney, NSW, Australia
Titolo Testata:
MEDICAL JOURNAL OF AUSTRALIA
fascicolo: 8, volume: 173, anno: 2000,
pagine: 433 - 436
SICI:
0025-729X(20001016)173:8<433:CI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID-ARTHRITIS; DOUBLE-BLIND; CELECOXIB; ROFECOXIB; NSAIDS; CYCLOOXYGENASE-2; OSTEOARTHRITIS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Brooks, PM Univ Queensland, Royal Brisbane Hosp, Fac Hlth Sci, Edith Cavell Bldg, Herston, Qld 4029, Australia Univ Queensland Edith Cavell Bldg Herston Qld Australia 4029 ia
Citazione:
P.M. Brooks e R.O. Day, "COX-2 inhibitors", MED J AUST, 173(8), 2000, pp. 433-436

Abstract

Cyclooxygenase-2 (COX-2) inhibitors constitute a new group of non-steroidal anti-inflammatory drugs (NSAIDs) which, at recommended doses, block prostaglandin production by cyclooxygenase-2, but not by cyclooxygenase-1. Two COX-2 inhibitors are currently available in Australia - celecoxib, which is taken twice daily, and rofecoxib, which is taken once daily. Both drugs act rapidly in providing pain relief and their antiinflammatory analgesic effect in osteoarthritis and rheumatoid arthritis is equivalent to standard doses of non-selective NSAIDs. Celecoxib and rofecoxib show significantly lower incidences of gastrotoxicity (as measured by endoscopic studies and gastrointestinal ulcers and bleeds) than non-selective NSAIDs. There is Level 2 evidence that COX-2 inhibitors:reduce pain in classic pain models - third-molar extraction, dysmenorrhoeaand after orthopaedic surgery;reduce pain and disability in osteoarthritis of the hip and knee; andreduce pain and disability in rheumatoid arthritis. Other adverse effects, such as interference with antihypertensive agents and the potential to produce renal dysfunction in patients with compromised renal function by COX-2 inhibitors, seem similar to those of non-selective NSAIDs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:47:02