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Titolo:
Increase of reactive oxygen (ROS) and nitrogen (RNS) species generated by phagocyting granulocytes related to age
Autore:
Chaves, MM; Rocha-Vieira, E; dos Reis, AP; Silva, RDE; Gerzstein, NC; Nogueira-Machado, JA;
Indirizzi:
Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-30161970 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-30161970 BC, MG, Brazil Santa Casa Hosp Belo Horizonte, Belo Horizonte, MG, Brazil Santa Casa HospBelo Horizonte Belo Horizonte MG Brazil onte, MG, Brazil
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 1-2, volume: 119, anno: 2000,
pagine: 1 - 8
SICI:
0047-6374(20001020)119:1-2<1:IORO(A>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS NITRIC-OXIDE; DIETARY RESTRICTION; MODULATION; BALANCE;
Keywords:
aged; granulocyte; inflammation; reactive oxygen species (ROS); reactive nitrogen species (RNS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Chaves, MM Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Av Antonio Carlos 6627,CP 486, BR-30161970 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Av Antonio Carlos 6627,CP 486 Belo Horizonte MG Brazil BR-30161970 BC
Citazione:
M.M. Chaves et al., "Increase of reactive oxygen (ROS) and nitrogen (RNS) species generated by phagocyting granulocytes related to age", MECH AGE D, 119(1-2), 2000, pp. 1-8

Abstract

In this present paper the age-induced effect on reactive oxidizing speciesgenerated by oxygen (ROS) and nitrogen (RNS) was studied using human phagocyting granulocytes. The ROS and RNS were quantified, respectively, in a chemiluminescence assay and by the measurement of nitrite production. The age-induced reactive oxidizing species generation was studied in healthy subjects ranging from 20 to 80 years old, divided into six age groups: group I, 20-29 years old; group II, 30-39 years old; group III, 40-49 years old; group IV, 50-59 years old; group V, 60-69 years old, and group VI, 70-80 yearsold. Our results demonstrate a parallelism between generation of the ROS and RNS induced by the age. A significant increase of ROS production was observed from 40 years old (age groups III, IV, V and VI while for RNS this increase was observed only from 50 years old (groups IV, V and VI). These data suggest an increase of oxidizing species generation (ROS/RNS) related to age. The increased generation of ROS (40-49 years old) was induced before the increasing of RNS (50-59 years old) and it may have consequences on inflammation and host defences. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:15:59