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Titolo:
Pimobendan inhibits the activation of transcription factor NF-kappa B - A mechanism which explains its inhibition of cytokine production and inducible nitric oxide synthase
Autore:
Matsumori, A; Nunokawa, Y; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068397, Japan Kyoto Univ Kyoto Japan 6068397 ovasc Med, Sakyo Ku, Kyoto 6068397, Japan Suntory Inst Biomed Res, Osaka 6188503, Japan Suntory Inst Biomed Res Osaka Japan 6188503 ed Res, Osaka 6188503, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 20, volume: 67, anno: 2000,
pagine: 2513 - 2519
SICI:
0024-3205(20001006)67:20<2513:PITAOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; VIRAL MYOCARDITIS; PROTEIN-KINASE; CHRONIC STAGE; CARDIOMYOPATHY; PHOSPHORYLATION; EXPRESSION; CHANNEL; MUSCLE; MODEL;
Keywords:
heart failure; inotropic drugs; pimobendan; interleukins; nitric oxide; NF-kappa B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumori, A Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawahara Cho Shogoin, Kyoto 6068397, Japan Kyoto Univ 54 Kawahara Cho Shogoin Kyoto Japan 6068397 Japan
Citazione:
A. Matsumori et al., "Pimobendan inhibits the activation of transcription factor NF-kappa B - A mechanism which explains its inhibition of cytokine production and inducible nitric oxide synthase", LIFE SCI, 67(20), 2000, pp. 2513-2519

Abstract

Pimobendan, an inhibitor of phosphodiesterase III with calcium sensitizingproperties, inhibits the production of cytokines and nitric oxide. In the present study, the effects of pimobendan and other inotropic agents on the activation of transcription factor NF-kappa B were examined. Pimobendan significantly decreased the expression of luciferase protein in A549 cells transfected with the NF-kappa B reporter plasmid, stimulated with interleukin (LL)-1 beta, tumor necrosis factor-alpha, or phorbol 12-myristate 13 acetate. However, high concentrations of amrinone, vesnarinone, or NKH 477 decreased promoter activity only slightly. Electrophoretic mobility shift assay also showed inhibition of NF-kappa B activation by pimobendan. Pimobendan possesses the unique property of inhibiting NF-kappa B, which may be independent of phosphodiesterase inhibition. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:45:16