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Titolo:
Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype inmultiple sclerosis
Autore:
Celius, EG; Harbo, HF; Egeland, T; Vartdal, F; Vandvik, B; Spurkiand, A;
Indirizzi:
Ullevaal Sykehus, Oslo City Hosp, Dept Neurol, Oslo, Norway Ullevaal Sykehus Oslo Norway Oslo City Hosp, Dept Neurol, Oslo, Norway Univ Oslo, Natl Hosp, Inst Immunol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Natl Hosp, Inst Immunol, Oslo, Norway Univ Oslo, Natl Hosp, Ctr Epidemiol, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Natl Hosp, Ctr Epidemiol, Oslo, Norway
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 178, anno: 2000,
pagine: 132 - 135
SICI:
0022-510X(20000915)178:2<132:SAAADA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA-ANTIGENS; SUSCEPTIBILITY; DISEASE; PROFILES; HETEROGENEITY; PROGRESSION; PROGNOSIS; JAPAN; ONSET; IGG;
Keywords:
multiple sclerosis; HLA class II association; age at diagnosis; gender; disease type; oligoclonal bands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Celius, EG Ullevaal Sykehus, Oslo City Hosp, Dept Neurol, Oslo, Norway Ullevaal Sykehus Oslo Norway Hosp, Dept Neurol, Oslo, Norway
Citazione:
E.G. Celius et al., "Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype inmultiple sclerosis", J NEUR SCI, 178(2), 2000, pp. 132-135

Abstract

The KLA-DR2, DQ6 (i.e., HLA-DRB1*1501, DQA1*0102, DQB1*0602) haplotype contributes to the risk of developing multiple sclerosis (MS) in Caucasoids ofNorthern European heritage. A correlation between the clinical expression of MS and the presence of HLA-DR2, DQ6 has, however, not convincingly been shown. In this study conventional bivariate analysis and logistic regression analysis were used to study the relationship between HLA-DR2, DQ6 and four disease variables in a cohort of 286 Norwegian MS patients from the Oslo area. Logistic regression analysis showed that HLA-DR2, DQ6 was significantly more frequent among female than male patients (P=0.0251), and was negatively correlated with age at diagnosis regardless of sex (P=0.0254). No significant correlation was observed between KLA-DR2, DQ6 and type of disease (relapsing-remitting versus primary chronic progressive MS) or presence/absence of oligoclonal bands in the cerebrospinal fluid. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:35:55