Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Urinary uric acid/creatinine ratio as an additional marker of perinatal asphyxia
Autore:
Chen, HJ; Yau, KIT; Tsai, KS;
Indirizzi:
Cardinal Tien Hosp, Dept Pediat, Taipei 28137, Taiwan Cardinal Tien Hosp Taipei Taiwan 28137 Dept Pediat, Taipei 28137, Taiwan Prov Tao Yuan Hosp, Dept Pediat, Tao Yuan, Taiwan Prov Tao Yuan Hosp Tao Yuan Taiwan Hosp, Dept Pediat, Tao Yuan, Taiwan Natl Taiwan Univ Hosp, Dept Lab Med, Taipei, Taiwan Natl Taiwan Univ HospTaipei Taiwan Hosp, Dept Lab Med, Taipei, Taiwan
Titolo Testata:
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
fascicolo: 10, volume: 99, anno: 2000,
pagine: 771 - 774
SICI:
0929-6646(200010)99:10<771:UUARAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWBORN-INFANTS; ACID; HYPOXANTHINE; XANTHINE; EXCRETION; LACTATE; HYPOXIA; SYSTEM; PLASMA; PIGS;
Keywords:
uric acid; creatinine; perinatal asphyxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Yau, KIT Cardinal Tien Hosp, Dept Pediat, 362 Chung Cheng Rd, Taipei 28137, Taiwan Cardinal Tien Hosp 362 Chung Cheng Rd Taipei Taiwan 28137 Taiwan
Citazione:
H.J. Chen et al., "Urinary uric acid/creatinine ratio as an additional marker of perinatal asphyxia", J FORMOS ME, 99(10), 2000, pp. 771-774

Abstract

Purpose: To study the validity of urinary uric acid (UA) as a marker of perinatal asphyxia in term and premature infants. Methods: The urinary ratio of UA to creatinine (Cr) was obtained within 24hours after birth in four groups of infants: 17 term infants and 18 premature infants with perinatal asphyxia, and 22 healthy term infants and 20 premature infants without perinatal asphyxia. Perinatal asphyxia was defined as an Apgar score of 3 or less at 1 minute or 5 or less at 5 minutes, and/ora first blood gas pH of less than 7.25 and a base deficit of at least 12 mmol/L. Results; The urinary ratio of UA to Cr was significantly higher in term infants with perinatal asphyxia than in term infants without asphyxia (1.53 +/- 0.71 vs 0.73 +/- 0.45; p < 0.005). The same result was found between premature infants with and without perinatal asphyxia (3.89 +/- 1.84 vs 2.45 +/- 0.88; p < 0.01). The urinary ratio of UA to Cr in premature infants was significantly higher than in term infants. When the urinary ratio of UA to Cr was greater than 0.95, perinatal asphyxia was identified with a sensitivity of 80% and a specificity of 71% in term infants. In premature infants, a cut-off value of UA/Cr for perinatal asphyxia of 2.9 had a sensitivity of71% and a specificity of 70%. Conclusions: The results of this study indicate that the urinary ratio of UA to Cr may be used as an additional marker of perinatal asphyxia in term and premature infants. In comparison with other markers such as xanthine, hypoxanthine, and ascorbic acid, it is a simple, quick, and inexpensive way to detect hypoxic episodes in a neonatal intensive care unit within 24 hours after birth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:06:54