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Titolo:
Histochemical correlates of O-15-water-perfusable tissue fraction in experimental canine studies of old myocardial infarction
Autore:
Iida, H; Tamura, Y; Kitamura, K; Bloomfield, PM; Eberl, S; Ono, Y;
Indirizzi:
Natl Cardiovasc Ctr, Res Inst, Dept Investigat Radiol, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 5658565 Suita, Osaka 5658565, Japan Res Inst Brain & Blood Vessels, Akita, Japan Res Inst Brain & Blood Vessels Akita Japan Blood Vessels, Akita, Japan Shimadzu Corp, Kyoto, Japan Shimadzu Corp Kyoto JapanShimadzu Corp, Kyoto, Japan Hammersmith Hosp, MRC, Cyclotron Unit, London W12 0HS, England HammersmithHosp London England W12 0HS on Unit, London W12 0HS, England Royal Prince Alfred Hosp, Sydney, NSW, Australia Royal Prince Alfred HospSydney NSW Australia sp, Sydney, NSW, Australia
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 10, volume: 41, anno: 2000,
pagine: 1737 - 1745
SICI:
0161-5505(200010)41:10<1737:HCOOTF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; CEREBRAL BLOOD-FLOW; NONINVASIVE QUANTIFICATION; F-18 FLUORODEOXYGLUCOSE; INTRAVENOUS (H2O)-O-15; PARAMETER-ESTIMATION; COMPUTED-TOMOGRAPHY; VIABLE MYOCARDIUM; ERROR ANALYSIS;
Keywords:
myocardial infarction; water-perfusable tissue fraction; O-15-labeled water; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Iida, H Natl Cardiovasc Ctr, Res Inst, Dept Investigat Radiol, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishiro Dai Suita Osaka Japan 5658565
Citazione:
H. Iida et al., "Histochemical correlates of O-15-water-perfusable tissue fraction in experimental canine studies of old myocardial infarction", J NUCL MED, 41(10), 2000, pp. 1737-1745

Abstract

A method has been proposed to quantitate the myocardial water-perfusable tissue fraction (PTF) in the area of hypoperfused asynergic segments using O-15-water ((H2O)-O-15) and PET. This study investigated the histochemical correlates of PTF (and perfusable tissue index, PTI) in a canine model of old myocardial infarction, Methods: Myocardial infarction was produced in 12 mongrel dogs, and PET was performed I mo later, providing quantitative parametric images of PTF, regional myocardial blood flow (MBF), and extravascular density from (H2O)-O-15, O-15-carbon monoxide, and transmission datasets. At the end of scanning, the myocardium was sectioned, and the PET images were compared directly with the corresponding myocardial sections. Results:The distribution of tissue necrosis identified by histochemical staining corresponded well with the defect in PTF but not in MBF. PTF agreed with theequilibrium images of myocardial (H2O)-O-15 distribution, obtained after injection of a large bolus of (H2O)-O-15. The defect surface area identifiedon PTF agreed well quantitatively with the morphometric estimates of the surface area of myocardial infarction. PTI agreed with the absolute proportion of histochemically defined normal myocardium (0.87 +/- 0.09 and 0.83 +/-0.08, respectively; P < 0.01). Both PTF and PTI decreased significantly insegments of myocardial infarction and showed a significant difference between the transmural and nontransmural myocardial infarction. Conclusion: Theabsolute mass and proportion of histochemically defined noninfarcted tissue may be quantitated with PTF and PTI in the area of myocardial infarction segments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:42:40