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Titolo:
Pulmonary distribution and kinetics of inhaled [C-11]triamcinolone acetonide
Autore:
Berridge, MS; Lee, Z; Heald, DL;
Indirizzi:
Univ Hosp Cleveland, Div Radiol, Case Western Reserve Univ, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 Univ, Cleveland, OH 44106 USA Rhone Poulenc Rorer Pharmaceut Inc, Med Affairs, Collegeville, PA USA Rhone Poulenc Rorer Pharmaceut Inc Collegeville PA USA legeville, PA USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 10, volume: 41, anno: 2000,
pagine: 1603 - 1611
SICI:
0161-5505(200010)41:10<1603:PDAKOI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; TRIAMCINOLONE ACETONIDE; MUCOCILIARY CLEARANCE; SPACER; AEROSOL; DELIVERY; EFFICACY; ASTHMA; DEPOSITION;
Keywords:
PET; inhaler; pulmonary; biodistribution; triamcinolone acetonide; steroid; drug development; Azmacort;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Berridge, MS Univ Hosp Cleveland, Div Radiol, Case Western Reserve Univ, 11100 Euclid Ave, Cleveland, OH 44106 USA Univ Hosp Cleveland 11100 Euclid Ave Cleveland OH USA 44106 A
Citazione:
M.S. Berridge et al., "Pulmonary distribution and kinetics of inhaled [C-11]triamcinolone acetonide", J NUCL MED, 41(10), 2000, pp. 1603-1611

Abstract

Triamcinolone acetonide (TAA) is an anti-inflammatory steroid used for topical treatment of allergic rhinitis and asthma. Drug deposition onto targettissues is an important parameter, so methods for accurate deposition measurement are needed. Lung deposition is especially problematic to measure because of the large field of view and low relative drug penetration. Our main objective was to use PET to measure the deposition and postdeposition kinetics of TAA in the lung after administration from the Azmacort inhaler. The second objective was to evaluate changes in distribution caused by the inhalation spacer that is built into the product. Methods: C-11-labeled TAA was formulated as the Azmacort product, 5 healthy volunteers inhaled it, andPET scans were obtained of its distribution in the head and chest. Region-of-interest analysis with CT overlay was used to analyze the distribution and kinetics in the airway and lung. Results: From 10% to 15% of the inhaleddrug dose was deposited in target airway regions in a distally decreasing pattern. Deposition in the oral cavity was about 30% of the dose. Slow absorption or clearance of drug from target tissues was observed over time. Useof the inhalation spacer caused statistically significant increases in alltarget tissues (factor of 2-5) and a roughly 40% decrease in oral deposition. Measurable amounts of the drug remained in target regions throughout the scanning period. Conclusion: Local pulmonary distribution and kinetics ofinhaled drugs can be measured accurately by PET for drug development. The integrated actuator-spacer significantly enhanced deposition of TAA in target tissues and reduced deposition in the oropharyngeal region.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 01:25:17