Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Coronary microvascular reactivity to sympathetic stimulation in patients with idiopathic dilated cardiomyopathy
Autore:
Drzezga, AE; Blasini, R; Ziegler, SI; Bengel, FM; Picker, W; Schwaiger, M;
Indirizzi:
Tech Univ Munich, Klinikum Rechts Isar, Dept Nucl Med, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 ucl Med, D-81675 Munich, Germany Tech Univ Munich, Klinikum Rechts Isar, Dept Cardiol, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 Cardiol, D-81675 Munich, Germany
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 41, anno: 2000,
pagine: 837 - 844
SICI:
0161-5505(200005)41:5<837:CMRTSS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; ISCHEMIC-HEART-DISEASE; FAILING HUMAN-HEART; DOWN-REGULATION; ENDOTHELIUM; FAILURE; RESERVE; PET; QUANTIFICATION; HEMODYNAMICS;
Keywords:
PET; idiopathic dilated cardiomyopathy; cold pressor test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Drzezga, AE Tech Univ Munich, Klinikum Rechts Isar, Nukl Med Klin & Poliklin, Ismaningerstr 22, D-81675 Munich, Germany Tech Univ Munich Ismaningerstr 22 Munich Germany D-81675 many
Citazione:
A.E. Drzezga et al., "Coronary microvascular reactivity to sympathetic stimulation in patients with idiopathic dilated cardiomyopathy", J NUCL MED, 41(5), 2000, pp. 837-844

Abstract

The objective of this study was to assess noninvasively the microvascular reactivity to sympathetic stimulation in patients with idiopathic dilated cardiomyopathy (IDC) and in healthy volunteers, who underwent cardiac catheterization for exclusion of coronary artery disease. Methods: Myocardial flow was quantified with N-13-ammonia PET and tracer kinetic modeling at rest and in response to cold presser testing (CPT), Ten healthy Volunteers (8 men, 2 women; mean age +/- SD, 50.7 +/- 15 y) and 10 matched patients (8 men,2 women; mean age, 52.5 +/- 14 y) with IDC (mean left ventricular ejectionfraction, 0.30 +/- 0.12) were included in the study. Results: Myocardial perfusion at rest was not significantly different between the groups. However, myocardial vascular resistance (MVR) was significantly lower in IDC patients at rest than in healthy volunteers. In response to CPT a significant decrease in MVR was found in healthy volunteers (1.9 +/- 0.4 to 1.5 +/- 0.4 mm Hg x 100 g/mL; 22% decrease) but not in IDC patients (1.5 +/- 0.4 to 1.4+/- 0.3 mm Hg x 100 g/mL; 9% decrease). Consequently, the increase of the myocardial blood flow in response to CPT was significantly lower (P < 0.008) in IDC patients (56 +/-: 17 to 66 +/- 18 mL/100 g/min; 20% increase) compared with healthy volunteers (52 +/- 12 to 80 +/- 30 mL/100 g/min; 52% increase), whereas both showed comparable hemodynamic reactions. Conclusion: The data indicate that CPT in combination with N-13 PET imaging is a valuablenoninvasive tool for assessment of coronary microvascular reaction to sympathetic stimulation in IDC patients. Lower coronary vascular resistance wasfound in IDC patients at rest compared with healthy volunteers, suggestingpossible exhaustion of sympathetically induced dilation of the coronary microvasculature in IDC patients at rest. This mechanism may explain the impaired flow response to cold in IDC patients in the present study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:12:44