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Titolo:
Coronary microangiopathy in type 2 diabetic patients: Relation to glycemiccontrol, sex, and microvascular angina rather than to coronary artery disease
Autore:
Yokoyama, I; Yonekura, K; Ohtake, T; Yang, WD; Shin, WS; Yamada, N; Ohtomo, K; Nagai, R;
Indirizzi:
Univ Tokyo, Dept Cardiovasc Med, Bunkyo Ku, Tokyo, Japan Univ Tokyo Tokyo Japan yo, Dept Cardiovasc Med, Bunkyo Ku, Tokyo, Japan Univ Tokyo, Dept Radiol, Tokyo, Japan Univ Tokyo Tokyo JapanUniv Tokyo, Dept Radiol, Tokyo, Japan Univ Tokyo, Dept Metab Dis, Tokyo, Japan Univ Tokyo Tokyo JapanUniv Tokyo, Dept Metab Dis, Tokyo, Japan
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 6, volume: 41, anno: 2000,
pagine: 978 - 985
SICI:
0161-5505(200006)41:6<978:CMIT2D>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; HEART-DISEASE; N-13 AMMONIA; FAMILIAL HYPERCHOLESTEROLEMIA; CAROTID-ARTERY; YOUNG MEN; RESERVE; INSULIN; MELLITUS;
Keywords:
hyperglycemia; non-insulin-dependent diabetes mellitus; flow reserve; atherosclerosis; coronary microangiopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoyama, I Univ Tokyo, Dept Cardiovasc Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 7-3-1 Hongo, Tokyo, Japan
Citazione:
I. Yokoyama et al., "Coronary microangiopathy in type 2 diabetic patients: Relation to glycemiccontrol, sex, and microvascular angina rather than to coronary artery disease", J NUCL MED, 41(6), 2000, pp. 978-985

Abstract

Coronary microangiopathy is a major complication in diabetics. However, the presence of independent factors in association with coronary microangiopathy in patients with non-insulin-dependent diabetes mellitus (NIDDM) or thedifference in coronary microangiopathy between diabetics with coronary artery disease (GAD) and those with microvascular angina is unclear. Methods: Nineteen patients with NIDDM and microvascular angina, 18 patients with NIDDM and CAD, and 17 age-matched control subjects were studied. Myocardial segments that were perfused by angiographically normal coronary arteries werestudied. The baseline myocardial blood flow (MBF) and the MBF during dipyridamole administration were measured using PET and N-13-ammonia, after which the myocardial flow reserve (MFR) was calculated to assess coronary microangiopathy. Results: The baseline MBF was comparable among NIDDM patients with microvascular angina, NIDDM patients with GAD, and control subjects. However, the MBF during dipyridamole administration was significantly lower in NIDDM patients with microvascular angina (126 +/- 42.7 mL/min/100 g) thanthat in either NIDDM patients with CAD (210 +/- 70.1 mL/min/100 g; P < 0.01) or control subjects (293 +/- 159 mL/min/100 g; P < 0.01), as was the MFR(NIDDM with microvascular angina, 1.90 +/- 0.73; NIDDM with CAD, 2.59 +/- 0.81 [P < 0.01]; control subjects, 3.69 +/- 1.09 [P < 0.01]). Multivariate stepwise regression analysis showed that, among the factors considered, glycemic control was independently related to the MFR (r = 0.838; P< 0.05). Conclusion: Glycemic control appears to be essential for coronary microangiopathy in NIDDM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:31:06