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Titolo:
Detection of serial changes in absolute myocardial perfusion with Rb-82 PET
Autore:
deKemp, RA; Ruddy, TD; Hewitt, T; Dalipaj, MM; Beanlands, RSB;
Indirizzi:
Univ Ottawa, Inst Heart, Div Cardiol, Cardiac PET Ctr, Ottawa, ON K1Y 4W7,Canada Univ Ottawa Ottawa ON Canada K1Y 4W7 c PET Ctr, Ottawa, ON K1Y 4W7,Canada
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 8, volume: 41, anno: 2000,
pagine: 1426 - 1435
SICI:
0161-5505(200008)41:8<1426:DOSCIA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; BLOOD-FLOW; QUANTITATIVE-ANALYSIS; MULTICENTER TRIAL; N-13 AMMONIA; RESERVE; NITROGEN-13-AMMONIA; REST; REPRODUCIBILITY;
Keywords:
perfusion; myocardial blood flow; Rb-82; PET; serial imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: deKemp, RA Univ Ottawa, Inst Heart, Div Cardiol, Cardiac PET Ctr, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada Univ Ottawa 40 Ruskin St Ottawa ON Canada K1Y 4W7 Y 4W7, Canada
Citazione:
R.A. deKemp et al., "Detection of serial changes in absolute myocardial perfusion with Rb-82 PET", J NUCL MED, 41(8), 2000, pp. 1426-1435

Abstract

Serial changes in myocardial perfusion may represent an important marker of disease progression or regression or the effects of therapy for patients with coronary artery disease (CAD). Quantitative methods have not been developed for the assessment of serial changes in perfusion. The objective of this study was to use receiver operator characteristic (ROC) analysis to determine the sensitivity and specificity of direct paired comparisons (DPCs) to detect changes in absolute myocardial perfusion measured with Rb-82 PET. Methods: Repeated dynamic 82Rb PET scans were obtained on 8 dogs at rest and during hyperemia induced with dobutamine (n = 4) or atrial pacing (n = 4). Radiolabeled microspheres were used to verify perfusion changes. Polar maps of absolute Rb-82 retention and associated SD were estimated from the dynamic images. Paired comparisons were then performed using a t test on each of the 532 polar map sectors. Rest-rest and stress-stress differences were used to assess specificity and reproducibility, and stress-rest differences were used to assess sensitivity. Results: Rb-82 retention differences of20% over baseline were detected with 85%-90% sensitivity and specificity, using the optimal DPC probability value and image smoothness. The average 82Rb retention differences correlated well with microspheres (r = 0.74; P = 0.001). Reproducibility of the mean retention values was 4.7% +/- 2.1%. As reproducibility varies, the DPC probability value can be adjusted to maintain specificity. These ROC results are directly applicable to other image modalities that produce measurements with similar SEs (3.7% +/- 0.9%). Conclusion: The developed method of DPCs is sensitive and specific for the detection of changes in absolute myocardial perfusion measured with Rb-82 PET.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:13:41