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Titolo:
Test-retest reproducibility of extrastriatal dopamine D-2 receptor imagingwith [I-123]epidepride SPECT in humans
Autore:
Varrone, A; Fujita, M; Verhoeff, NPLG; Zoghbi, SS; Baldwin, RM; Rajeevan, N; Charney, DS; Seibyl, JP; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Diagnost Radiol, W Haven, CT 06516 USA Yale UnivW Haven CT USA 06516 ept Diagnost Radiol, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Med, Dept Psychiat, W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Pharmacol, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 Med, Dept Pharmacol, W Haven, CT 06516 USA VA Connecticut, W Haven, CT USA VA Connecticut W Haven CT USAVA Connecticut, W Haven, CT USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 8, volume: 41, anno: 2000,
pagine: 1343 - 1351
SICI:
0161-5505(200008)41:8<1343:TROEDD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; I-123 EPIDEPRIDE; D2 RECEPTORS; AUTOMATED ALGORITHM; BINDING; QUANTIFICATION; RADIOTRACERS; RADIOLIGAND; TOMOGRAPHY; POSTMORTEM;
Keywords:
[I-123]epidepride; dopaminergic system; reproducibility; D-2 receptor quantification;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Varrone, A Vet Adm Med Ctr, 116 A2,950 Campbell Ave, W Haven, CT 06516 USAVet Adm Med Ctr 116 A2,950 Campbell Ave W Haven CT USA 06516 SA
Citazione:
A. Varrone et al., "Test-retest reproducibility of extrastriatal dopamine D-2 receptor imagingwith [I-123]epidepride SPECT in humans", J NUCL MED, 41(8), 2000, pp. 1343-1351

Abstract

This study evaluated the test-retest reproducibility of D-2 receptor quantification in the thalamus and temporal cortex using [I-123]epidepride SPECT. Methods: Ten healthy volunteers (4 men, 6 women; age range, 19-46 y) underwent 2 SPECT studies (interval, 2-26 d) using a bolus-plus-constant-infusion paradigm (bolus-to-infusion ratio = 6 h; infusion time = 9 h). Plasma clearance (in liters per hour) and free fraction (f(1)) of the parent tracer were measured. Radioactivity (in becquerels per gram) in the thalamus, temporal cortex, and cerebellum were normalized to the infusion rate (in becquerels per hour). Normalized striatal radioactivity was also measured to assess reproducibility in regions with a high density of receptors and better counting statistics. The outcome measures obtained were V-3 (receptor density [B-max]/equilibrium dissociation constant [K-D]), V-3' (f(1) X B-max/K-D), and R-T (Specific-to-nondisplaceable tissue ratio). Results: Test-retest variability and reliability (intraclass correlation coefficient) were 10.8%and 0.88, respectively, for plasma clearance and 15.3% and 0.77, respectively, for f(1). The test-retest variability of brain-specific (target minus nondisplaceable) radioactivity was higher in the thalamus and temporal cortex than in the striatum, although reliability was comparable. Among the outcome measures, V-3' showed better test-retest variability and reliability in the thalamus (13.3% and 0.75, respectively) and temporal cortex (13.4% and 0.86, respectively). Conclusion: Brain radioactivity was the main source of variability for quantification of extrastriatal D-2 receptors with [I-123]epidepride. The reproducibility of outcome measures in extrastriatal regions was good. However, because receptor density was lower in extrastriatal regions than in the striatum, the counting statistics in these regions werelow and reproducibility was affected by the higher test-retest variabilityof brain-specific radioactivity. Compared with V-3 and V-3', R-T showed less test-retest variability in the thalamus and temporal cortex but lower reliability. Moreover, measurement of R-T may be affected by the presence of potential lipophilic metabolites entering the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:29:24