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Titolo:
Reduced nerve growth factor in Rett syndrome postmortem brain tissue
Autore:
Lipani, JD; Bhattacharjee, MB; Corey, DM; Lee, DA;
Indirizzi:
Tulane Univ, Med Ctr, Dept Psychiat & Neurol, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 & Neurol, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Div Neurosci, New Orleans, LA 70118 USA Tulane UnivNew Orleans LA USA 70118 Neurosci, New Orleans, LA 70118 USA Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70118 USA Tulane Univ New Orleans LA USA 70118 pt Pathol, New Orleans, LA 70118 USA Tulane Univ, Sch Med, Dept Psychiat & Neurol, New Orleans, LA 70118 USA Tulane Univ New Orleans LA USA 70118 & Neurol, New Orleans, LA 70118 USA
Titolo Testata:
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
fascicolo: 10, volume: 59, anno: 2000,
pagine: 889 - 895
SICI:
0022-3069(200010)59:10<889:RNGFIR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE AXONAL-TRANSPORT; MESSENGER-RNA; CEREBROSPINAL-FLUID; X-CHROMOSOME; HISTONE DEACETYLASE; BASAL FOREBRAIN; PC12 CELLS; EXPRESSION; MECP2; RATS;
Keywords:
astrogliosis; GFAP; NGF; Rett syndrome; trkA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, DA Tulane Univ, Med Ctr, Dept Psychiat & Neurol, 1400 Canal St, New Orleans, LA 70112 USA Tulane Univ 1400 Canal St New Orleans LA USA 70112 s, LA 70112 USA
Citazione:
J.D. Lipani et al., "Reduced nerve growth factor in Rett syndrome postmortem brain tissue", J NE EXP NE, 59(10), 2000, pp. 889-895

Abstract

To determine whether reduced nerve growth factor (NGF) and/or its high affinity receptor, trkA, play a role in the pathophysiology of Rett syndrome (RS), we used immunohistochemistry in paraffin-embedded human autopsy brain tissue to quantify NGF and trkA levels within the frontal cortex of 9 RS females and 10 female controls of similar age. The results showed a significant reduction of NGF expression in RS patients (p < 0.001). Specifically, all RS brains exhibited NGF levels at or below the minimum level observed in controls. In 3 RS brains there was no NGF detected. TrkA expression was also reduced in the RS group (p = 0.035). Interestingly, the expression of NGFin the RS group was significantly related to the presence of cortical astrogliosis (r = 0.91) as indicated by immunostaining for glial fibrillary acidic protein (GFAP). This suggests that while the signals for NGF productionduring injury remain intact, the critical developmental signals required for early NGF production are impaired.

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Documento generato il 19/01/20 alle ore 20:03:50