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Titolo:
Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex
Autore:
Ghee, M; Fournier, A; Mallet, J;
Indirizzi:
Hop La Pitie Salpetriere, Lab Gent Mol Neurotransmiss & Proc Neurdegenerat, CNRS, UMR 9923, F-75013 Paris, France Hop La Pitie Salpetriere Paris France F-75013 923, F-75013 Paris, France Aventis Pharma Res & Dev, Vitry Sur Seine, France Aventis Pharma Res & Dev Vitry Sur Seine France Vitry Sur Seine, France
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 5, volume: 75, anno: 2000,
pagine: 2221 - 2224
SICI:
0022-3042(200011)75:5<2221:RAIWTB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; 26-S PROTEASE; LEWY BODIES; IN-VITRO; FAMILY; DEGRADATION; IDENTIFICATION; INCLUSIONS; MODULATOR; ACTIVATOR;
Keywords:
alpha-synuclein; Parkinson's disease; Tat binding protein 1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mallet, J Hop La Pitie Salpetriere, Lab Gent Mol Neurotransmiss & Proc Neurdegenerat, CNRS, UMR 9923, Batiment CERVI,83 Blvd Hop, F-75013 Paris, France Hop La Pitie Salpetriere Batiment CERVI,83 Blvd Hop Paris France F-75013
Citazione:
M. Ghee et al., "Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex", J NEUROCHEM, 75(5), 2000, pp. 2221-2224

Abstract

The alpha-synuclein gene, which encodes a brain presynaptic nerve terminalprotein of unknown function, is linked to familial early-onset Parkinson'sdisease (PD). The finding that alpha-synuclein forms the major fibrillary component of Lewy bodies in brains of PD patients suggests that the two point mutations in alpha-synuclein (Ala(53)Thr, Ala(30)Pro) may promote the aggregation of alpha-synuclein into filaments. To address the role of alpha-synuclein in neurodegenerative diseases, we performed a yeast two-hybrid screen of a rat adult brain cDNA library using rat alpha-synuclein 2 (alpha SYN2). Here we report that alpha SYN2 interacts specifically with Tat bindingprotein 1, a subunit of the 700-kDa proteasome activator (PA700), the regulatory complex of the 26S proteasome and of the modulator complex, which enhances PA700 activation of the proteasome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 05:24:07