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Titolo:
Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis
Autore:
Hochstenbag, MMH; Twijnstra, A; Wilmink, JT; Wouters, EFM; ten Velde, GPM;
Indirizzi:
Univ Hosp Maastricht, Dept Pulm, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Neurol, NL-6202 AZ Maastricht, Netherlands UnivHosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Radiol, NL-6202 AZ Maastricht, Netherlands UnivHosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 48, anno: 2000,
pagine: 243 - 248
SICI:
0167-594X(200007)48:3<243:ABM(IS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLACTIC CRANIAL IRRADIATION; COMPLETE REMISSION; CNS METASTASES; CARCINOMA; SURVIVAL; CHEMOTHERAPY;
Keywords:
SCLC; brain matastases; neurologic asympotomatic; MRI; prophylactic radiotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Hochstenbag, MMH Univ Hosp Maastricht, Dept Pulm, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
M.M.H. Hochstenbag et al., "Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis", J NEURO-ONC, 48(3), 2000, pp. 243-248

Abstract

Purpose. In this study we evaluated the usefulness of MR-imaging in the detection of asymptomatic brain metastases (BM) at the initial diagnosis in patients with small cell lung cancer (SCLC) and studied the follow-up of these patients. Patients and methods. One-hundred and twenty-five patients with SCLC were investigated with MR-imaging. Results. In 112 patients with normal neurological findings, MR-imaging of the brain demonstrated BM in 17 patients (15%). Six of these 17 patients were therefore upgraded to extensive disease (ED). Two of these 17 patients died during chemotherapy because of progressive disease and 3 patients became neurologic symptomatic with progressive disease on MR-imaging of the brain. After completion of chemotherapy a repeated MR-imaging of the brain in the remaining 12 patients showed 1 complete remission, 4 partial remission and 7 progressive disease of the BM. Conclusion. This study showed that at presentation an unexpectedly high percentage of SCLC patients had asymptomatic BM on MR-imaging. We propose that MR-imaging of the brain should be included in the staging of SCLC patients as well for staging, prognosis and therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:17:01