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Titolo:
Radiosynthesis of a potent endothelin receptor antagonist: [C-11] L-753,037
Autore:
Ravert, HT; Mathews, WB; Hamill, TG; Burns, HD; Dannals, RF;
Indirizzi:
Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USAJohns Hopkins Med Inst Baltimore MD USA 21287 ed, Baltimore, MD 21287 USA Merck Res Labs, Dept Pharmacol, W Point, PA 19486 USA Merck Res Labs W Point PA USA 19486 Dept Pharmacol, W Point, PA 19486 USA
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 12, volume: 43, anno: 2000,
pagine: 1205 - 1210
SICI:
0362-4803(20001030)43:12<1205:ROAPER>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Keywords:
L-753,037; endothelin; carbon-11; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ravert, HT Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, 600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Med Inst 600 N Wolfe St BaltimoreMD USA 21287 SA
Citazione:
H.T. Ravert et al., "Radiosynthesis of a potent endothelin receptor antagonist: [C-11] L-753,037", J LABEL C R, 43(12), 2000, pp. 1205-1210

Abstract

[C-11]-L-753,037, [(+)-(5S,6R,7R)-2-butyl-7-[2-((2S)-2-carboxypropyl)- 4-[C-11]-methoxyphenyl]-5-(3,4-methylenedioxyphenyl)-cylcopenteno- [1,2-b]pyridine-6-carboxylate], a potent mixed antagonist of endothelin receptor subtypes ETA and ETB, was synthesized by [C-11]-methylation of a phenolic precursor. The time for synthesis, purification, and formulation was 17 minutes with an average specific radioactivity of 2535 mCi/mu mol (EOS) and average decay corrected radiochemical yield of 3% based on [C-11]-methyl iodide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:36:51