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Titolo:
Chromatographic separation of 2,3-benzodiazepines
Autore:
Rizzo, M;
Indirizzi:
Univ Catanzaro Magna Groecia, Sch Pharm, Chair Med Chem, I-88021 Catanzaro, Italy Univ Catanzaro Magna Groecia Catanzaro Italy I-88021 21 Catanzaro, Italy
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 747, anno: 2000,
pagine: 203 - 216
SICI:
1387-2273(20000929)747:1-2<203:CSO2>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-PERFORMANCE LIQUID; AMPA RECEPTOR ANTAGONISTS; THIN-LAYER CHROMATOGRAPHY; EPILEPSY-PRONE RATS; N-ACETYL METABOLITE; ANTICONVULSANT ACTIVITY; ULTRAVIOLET DETECTION; PLASMA-LEVEL; GYKI 52466; DERIVATIVES;
Keywords:
reviews; 2,3-benzodiazepines;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Rizzo, M Univ Catanzaro Magna Groecia, Sch Pharm, Chair Med Chem, I-88021 Catanzaro, Italy Univ Catanzaro Magna Groecia Catanzaro Italy I-88021 aro, Italy
Citazione:
M. Rizzo, "Chromatographic separation of 2,3-benzodiazepines", J CHROMAT B, 747(1-2), 2000, pp. 203-216

Abstract

A review of chromatographic methods for the determination of 2,3-benzodiazepines (2,3-BZs) is presented. The determinations are performed to investigate the presence of potential impurities in drug substances and to study their pharmacokinetic profile in biological samples, either in animals or in humans. Several methods dealt with a pretreatment of samples, i.e., liquid-liquid extraction by using a variety of solvents, solid-phase extraction, direct injection of specimens into the chromatographic apparatus. Different chromatographic techniques have been used. High-performance liquid chromatography allows optimal sensitivity and specificity by using ultraviolet or diode array detection methods. Gas chromatography-mass spectrometry and gas chromatography with nitrogen-phosphorous or electron-capture detectors havebeen also reported. Suitable methods for the separation of enantiomers of 2,3-BZs have been described. Thin-layer chromatography has been shown to becapable to isolate analytes from biological samples as urine or faeces. The reported chromatographic techniques are currently applied to define the metabolic pathways of 2,3-BZs in experimental and clinical studies. (C) 2000Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:30:53