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Titolo:
Capillary electrochromatography and capillary electrochromatography-electrospray mass spectrometry for the separation of non-steroidal anti-inflammatory drugs
Autore:
Desiderio, C; Fanali, S;
Indirizzi:
CNR, Area Ric Roma, Ist Cromatog, I-00016 Monterotondo, Rome, Italy CNR Monterotondo Rome Italy I-00016 og, I-00016 Monterotondo, Rome, Italy
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 895, anno: 2000,
pagine: 123 - 132
Fonte:
ISI
Lingua:
ENG
Keywords:
electrochromatography; background electrolyte composition; non-steroidal anti-inflammatory drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Fanali, S CNR, Area Ric Roma, Ist Cromatog, POB 10, I-00016 Monterotondo, Rome, Italy CNR POB 10 Monterotondo Rome Italy I-00016 erotondo, Rome, Italy
Citazione:
C. Desiderio e S. Fanali, "Capillary electrochromatography and capillary electrochromatography-electrospray mass spectrometry for the separation of non-steroidal anti-inflammatory drugs", J CHROMAT A, 895(1-2), 2000, pp. 123-132

Abstract

In this study capillary electrochromatography (CEC) was utilized for the separation of ten non-steroidal anti-inflammatory drugs (NSAIDs). Experiments were carried out in a commercially available CE instrument using a packedcapillary with RP-18 silica particles where the stationary phase completely filled the capillary. The mobile phase consisted of a mixture of ammoniumformate buffer pH 2.5 and acetonitrile. Selectivity and resolution were studied changing the pH and the concentration of the buffer, the acetonitrilecontent mobile phase and the capillary temperature. The optimum experimental conditions for CEC separation of the studied drug mixture were found using 50 mM ammonium formate pH 2.5-acetonitrile (40:60) at 25 degreesC. The CEC capillary was coupled to an electrospray mass spectrometer for the characterization of the NSAIDs. A mobile phase composed by the same buffer but with a higher concentration of acetonitrile (90%) was used in order to speedup the separation of analytes. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 09/07/20 alle ore 20:28:02