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Titolo:
MR FIRST PASS IMAGING - QUANTITATIVE ASSESSMENT OF TRANSMURAL PERFUSION AND COLLATERAL FLOW
Autore:
JEROSCHHEROLD M; WILKE N;
Indirizzi:
UNIV MINNESOTA,DEPT RADIOL,420 DELAWARE ST SE,UMHC BOX 292 MINNEAPOLIS MN 55455 UNIV MINNESOTA,CTR MAGNET RESONANCE RES MINNEAPOLIS MN 55455
Titolo Testata:
International journal of cardiac imaging
fascicolo: 3, volume: 13, anno: 1997,
pagine: 205 - 218
SICI:
0167-9899(1997)13:3<205:MFPI-Q>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; MYOCARDIAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; MEAN TRANSIT-TIME; CONTRAST ECHOCARDIOGRAPHY; NONINVASIVE QUANTIFICATION; COMPUTED-TOMOGRAPHY; N-13 AMMONIA; GD-DTPA; RESERVE;
Keywords:
MYOCARDIUM; MR-HEART; PERFUSION-MYOCARDIUM; BLOOD SUPPLY MAGNETIC RESONANCE; CONTRAST ENHANCEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
M. Jeroschherold e N. Wilke, "MR FIRST PASS IMAGING - QUANTITATIVE ASSESSMENT OF TRANSMURAL PERFUSION AND COLLATERAL FLOW", International journal of cardiac imaging, 13(3), 1997, pp. 205-218

Abstract

Recent advances with fast switching gradient coils, and the optimization of magnetic resonance techniques for multislice imaging have made it possible to apply models of contrast agent transit for the quantification of myocardial perfusion, and determination of the transmural distribution of blood flow. This article summarizes some of these recentdevelopments and presents examples of quantitative, multi-slice myocardial perfusion imaging studies in patients and animal models. Multi-slice, true first pass imaging, with high temporal resolution, and T-1-weighted, arrhythmia insensitive contrast enhancement is used for the quantification of perfusion changes accompanying mild to severe ischemia. The first pass imaging technique and the modeling approach are sufficiently robust for fitting of tissue residue curves corresponding toa wide, physiologically realistic range of myocardial blood flows. Inanimals this was validated by comparison to blood flow measurements with radiorabeled microspheres as gold standard. It is demonstrated that with the proposed modeling approach one can determine the myocardialperfusion reserve from two consecutive MR first pass measurements under resting and hyperemic conditions. In patients with microvascular dysfunction the MR studies show for the first time that the myocardial perfusion reserve correlates with Doppler flow measurements (linear regression with slope of 1.02 +/- 0.09; r = 0.80). Since perfusion limitations usually begin in the subendocardium as coronary flow is gradually reduced, first pass imaging with the prerequisitie spatial and temporal resolution allows early detection of a mild coronary stenosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:49:04